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F4772 Sigma

Monoclonal Anti-Cytokeratin Peptide 18−FITC antibody produced in mouse

clone CY-90, purified immunoglobulin, buffered aqueous solution

Synonym: Monoclonal Anti-Cytokeratin Peptide 18

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cytokeratins,
species reactivity   wide range
application(s)   direct immunofluorescence: 1:100 using formalin-fixed, paraffin-embedded sections of human or animal tissues
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
clone   CY-90, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   dry ice
storage temp.   −20°C
biological source   mouse
conjugate   FITC conjugate

Description

Immunogen

human epidermal carcinoma A-431 and MCF-7 human breast cancer cell lines.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 0.01% thimerosal.

Application

Monoclonal Anti-Cytokeratin Peptide 18-FITC antibody:
• is suitable for immunohistochemistry to identify renal tubular epithelial cells in the extrarenal cells regeneration during acute renal failure.
• is suitable for immunocytochemical and immuno-electron microscopic localisation of keratins in human materno-foetal interaction zone.
• may be used for single or double labeling procedures.

Features and Benefits

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Biochem/physiol Actions

Cytokeratins also called keratins (Ks) according to the new nomenclature system.These are known to be the major structural proteins of epithelial cells. It is heteropolymeric in nature i.e. in cells more than one keratin protein is always present. It belongs to type I acrylic sub-family and is differentially expressed in various human tissues. It maintains the structural integrity of extra-embryonic membrane epithelia. Broadly keratins are grouped into two types on the basis of their biochemical and immunological properties: Type II keratins are a family of basic proteins identified as K1 to K8, whereas type I keratins consists of K9 to K20, belong to the acidic group.

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