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F4930 Sigma

FES, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: FPS

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   48-64 nmol/min·mg
mol wt   mol wt ~125 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... FES(2242)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

FES regulates the growth and differentiation of neurons, hematopoietic, vascular endothelial and epithelial cell lines. Inactivation of this gene leads to suppression of human renal carcinoma cell proliferation, and thus, might have potential as a therapeutic target. It is a highly regulated oncogene, and in transgenic mice, its up-regulation leads to tissue hyperplasia, hemangioma formation and oncogenic transformation of fibroblasts. It however, acts as a tumor suppressor in colorectal cancer (CRC), where it is inactivated due to promoter methylation.

General description

FES is a protein-tyrosine kinase, which was first identified as a homolog of transforming oncogene in avian and feline retrovirus. It is a 93kDa protein, which is expressed in endothelial, epithelial, myeloid, vascular and neuronal cells.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles
Peer-Reviewed Papers
15

References

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