5-Fluorouracil

Papers

Effects of perturbations of pools of deoxyribonucleoside triphosphates on expression of ribonucleotide reductase, a G1/S transition state enzyme, in p53-mutated cells. Wadler, S., et al. Biochem. Pharmacol. 55, 1353-1360, (1998)

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Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells. Elstein, K.H., et al. Toxicol. Appl. Pharmacol. 146, 29-39, (1997)

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Effect of 5-fluorouracil on cell cycle regulatory proteins in human colon cancer cell line. Takeda, H., et al. Jpn. J. Cancer Res. 90, 677-684, (1999)

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Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity. Pritchard, D.M., et al. Toxicol. Lett. 102-103, 19-27, (1998)

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5-FU-induced apoptosis correlates with efficacy against human gastric and colon cancer xenografts in nude mice. Inada, T., et al. Anticancer Res. 17, 1965-1971, (1997)

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Selective Activation Of SHP2 Activity By Cisplatin Revealed By A Novel Chemical Probe-based Assay. Kuo, C.C., et al. Biochem. Biophys. Res. Commun. 391, 230-4, (2010)

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Arcobacter Population Dynamics In Pigs On Farrow-to-Finish Farms. De Smet, S., et al. Appl. Environ. Microbiol. 77, 1732-8, (2011)

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Differential Expression Of The Klf6 Tumor Suppressor Gene Upon Cell Damaging Treatments In Cancer Cells. Gehrau, R.C., et al. Mol. Cell. 707, 15-23, (2011)

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A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-β 2 responsiveness. Serine Avagyan et al J. Immunol. 181, 5904-11, (2008)

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Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. Celia Perales et al PLoS ONE 4, e5554, (2009)

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A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates. Peter M. Wilson et al Nucleic Acids Res. 39, e112, (2011)

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Antiproliferative property of hexadecyloxypropyl 9-[2-(phosphonomethoxy) ethyl] guanine (HDP-PMEG) for unwanted ocular proliferation. Jiangping Hou et al Mol. Vis. 17, 627-37, (2011)

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Parallel evolution under chemotherapy pressure in 29 breast cancer cell lines results in dissimilar mechanisms of resistance. Bálint Tegze et al PLoS ONE 7, e30804, (2012)

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Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer. Veeresa Gududuru et al J. Med. Chem. 48, 2584-8, (2005)

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Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: studies on the mode of drug action. Ingo Ott et al J. Med. Chem. 48, 622-9, (2005)

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Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin. Heyong Gao et al Bioorg. Med. Chem. Lett. 15, 2003-6, (2005)

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Synthesis and antitumor activity of the hexacyclic camptothecin derivatives. Heyong Gao et al Bioorg. Med. Chem. Lett. 15, 3233-6, (2005)

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SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: a novel class of cytotoxic agents for prostate cancer. Veeresa Gududuru et al Bioorg. Med. Chem. Lett. 15, 4010-3, (2005)

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Constituents of the pericarp of Garcinia subelliptica. Chien-Chang Wu et al J. Nat. Prod. 68, 1125-7, (2005)

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Cytotoxic prenylflavonoids from Artocarpus elasticus. Horng-Huey Ko et al J. Nat. Prod. 68, 1692-5, (2005)

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Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. Michael L Mohler et al J. Med. Chem. 49, 5845-8, (2006)

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Synthesis and biological activities of nucleoside-estradiol conjugates. Hasrat Ali et al Bioorg. Med. Chem. Lett. 16, 317-9, (2006)

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Synthesis, aerobic cytotoxicity, and radiosensitizing activity of novel 2,4-dinitrophenylamine tethered 5-fluorouracil and hydroxyurea. Ali Khalaj et al Bioorg. Med. Chem. Lett. 16, 6034-8, (2006)

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Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice. M Sri Balasubashini et al Bioorg. Med. Chem. Lett. 16, 6219-25, (2006)

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Study on synthesis and biological activity of a galactosylated piperazinyl porphyrin. He-Ping Li et al Bioorg. Med. Chem. Lett. 16, 6298-301, (2006)

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Gymnastatins F-H, cytostatic metabolites from the sponge-derived fungus Gymnascella dankaliensis. Taro Amagata et al J. Nat. Prod. 69, 1384-8, (2006)

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Bioactive triterpene glycosides from the sea cucumber Holothuria fuscocinerea. Shu-Yu Zhang et al J. Nat. Prod. 69, 1492-5, (2006)

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Bromophenols coupled with methyl gamma-ureidobutyrate and bromophenol sulfates from the red alga Rhodomela confervoides. Ming Ma et al J. Nat. Prod. 69, 206-10, (2006)

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Flavan-4-ol Glycosides from the Rhizomes of Abacopteris penangiana. Zhongxiang Zhao et al J. Nat. Prod. 69, 265-8, (2006)

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Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea. George R Pettit et al J. Nat. Prod. 69, 323-7, (2006)

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Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Strom, E., et al. Nat. Chem. Biol. 2, 474-479, (2006)

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Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set. Aliuska Morales Helguera et al J. Med. Chem. 50, 1537-45, (2007)

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Scaffold targeting drug-resistant colon cancers. Katerina Otrubova et al J. Med. Chem. 50, 1999-2002, (2007)

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Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives. Yi Bi et al Bioorg. Med. Chem. Lett. 17, 1475-8, (2007)

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Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Bhahwal A Shah et al Bioorg. Med. Chem. Lett. 17, 6411-6, (2007)

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Efficient synthesis and in vitro cytostatic activity of 4-substituted triazolyl-nucleosides. Khalid El Akri et al Bioorg. Med. Chem. Lett. 17, 6656-9, (2007)

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Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates. Christian Banekovich et al Bioorg. Med. Chem. Lett. 17, 683-7, (2007)

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Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents. Maojiang Wu et al Bioorg. Med. Chem. Lett. 17, 869-73, (2007)

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5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells. Srinivasarao Meneni et al Bioorg. Med. Chem. 15, 3082-8, (2007)

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An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents. Evangelia Tsoukala et al Bioorg. Med. Chem. 15, 3241-7, (2007)

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2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols. Palwinder Singh et al Bioorg. Med. Chem. 15, 3990-6, (2007)

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Design, syntheses, and antitumor activity of novel chromone and aurone derivatives. Wei Huang et al Bioorg. Med. Chem. 15, 5191-7, (2007)

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Exomethylene pyranonucleosides: efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-d-glycero-hex-3-enopyranosyl)thymine. George Agelis et al Bioorg. Med. Chem. 15, 5448-56, (2007)

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Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. François Liger et al Bioorg. Med. Chem. 15, 5615-9, (2007)

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Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. Yoshihito Nakagawa et al Bioorg. Med. Chem. 15, 5620-8, (2007)

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E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins. Amitabh Jha et al Bioorg. Med. Chem. 15, 5854-65, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Solvatochromism, DNA binding, antitumor activity and molecular modeling study of mixed-ligand copper(II) complexes containing the bulky ligand: bis[N-(p-tolyl)imino]acenaphthene. Usama El-Ayaan et al Eur. J. Med. Chem. 42, 1325-33, (2007)

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Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position. Xian-Feng Huang et al Eur. J. Med. Chem. 42, 263-7, (2007)

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Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study. Alaa A-M Abdel-Aziz et al Eur. J. Med. Chem. 42, 614-26, (2007)

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Synthetic 2',5'-dimethoxychalcones as G(2)/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages. Bai-Luh Wei et al Eur. J. Med. Chem. 42, 660-8, (2007)

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Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds. Umashankar Das et al Eur. J. Med. Chem. 42, 71-80, (2007)

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Synthetic studies on novel benzimidazolopeptides with antimicrobial, cytotoxic and anthelmintic potential. Rajiv Dahiya et al Eur. J. Med. Chem. 42, 772-98, (2007)

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Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. Nicolas Papon et al Antimicrob. Agents Chemother. 51, 369-71, (2007)

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Combination of amphotericin B with flucytosine is active in vitro against flucytosine-resistant isolates of Cryptococcus neoformans. Patrick Schwarz et al Antimicrob. Agents Chemother. 51, 383-5, (2007)

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Stellettins L and M, cytotoxic isomalabaricane-type triterpenes, and sterols from the marine sponge Stelletta tenuis. Hou-wen Lin et al J. Nat. Prod. 70, 1114-7, (2007)

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Cytotoxic benzo[j]fluoranthene metabolites from Hypoxylon truncatum IFB-18, an endophyte of Artemisia annua. W Gu et al J. Nat. Prod. 70, 114-7, (2007)

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Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships. Peng Liu et al J. Nat. Prod. 70, 533-7, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones. José C Aponte et al J. Med. Chem. 51, 6230-4, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies. Mónica Díaz-Gavilán et al Bioorg. Med. Chem. Lett. 18, 1457-60, (2008)

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Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates. Jinyi Xu et al Bioorg. Med. Chem. Lett. 18, 4741-4, (2008)

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Synthesis and cytotoxic activity of some novel polycyclic gamma-butyrolactones. M P S Ishar et al Bioorg. Med. Chem. Lett. 18, 4809-12, (2008)

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Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Suresh Awale et al Bioorg. Med. Chem. 16, 181-9, (2008)

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Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. Feng Li et al Bioorg. Med. Chem. 16, 5434-40, (2008)

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Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues. Tatjana Gazivoda et al Bioorg. Med. Chem. 16, 5624-34, (2008)

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Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog. Yuqiang Wang et al Bioorg. Med. Chem. 16, 6552-9, (2008)

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Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents. Jianhong Wang et al Bioorg. Med. Chem. 16, 7005-12, (2008)

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Synthesis and cytotoxic, anti-inflammatory, and anti-oxidant activities of 2',5'-dialkoxylchalcones as cancer chemopreventive agents. Jen-Hao Cheng et al Bioorg. Med. Chem. 16, 7270-6, (2008)

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The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis. David Díaz-Carballo et al Bioorg. Med. Chem. 16, 9635-43, (2008)

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Synthesis and molecular modelling of unsaturated exomethylene pyranonucleoside analogues with antitumor and antiviral activities. George Agelis et al Eur. J. Med. Chem. 43, 1366-75, (2008)

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Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines. Ana Conejo-García et al Eur. J. Med. Chem. 43, 1742-8, (2008)

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Unsaturated fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-4-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine and N(6)-benzoyl adenine. Stella Manta et al Eur. J. Med. Chem. 43, 420-8, (2008)

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Diterpenoids from the roots of Suregada glomerulata. Ren-Yi Yan et al J. Nat. Prod. 71, 195-8, (2008)

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Cytotoxic hydrolyzable tannins from Balanophora japonica. Zhi-Hong Jiang et al J. Nat. Prod. 71, 719-23, (2008)

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Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis. Heran Li et al J. Nat. Prod. 71, 739-41, (2008)

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Lanostane-type triterpenoids from the roots of Kadsura coccinea. Nan Wang et al J. Nat. Prod. 71, 990-4, (2008)

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A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Montagnoli, A., et al. Nat. Chem. Biol. 4, 357-365, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxic. Mech. Methods 18, 217-27, (2008)

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High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. Younis Baqi et al J. Med. Chem. 52, 3784-93, (2009)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies. Aurélien Putey et al J. Med. Chem. 52, 5916-25, (2009)

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Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities. Sham M Sondhi et al Bioorg. Med. Chem. Lett. 19, 1534-8, (2009)

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Porphyrins containing nitric oxide donors: Synthesis and cancer cell-oriented NO release. Wukun Liu et al Bioorg. Med. Chem. Lett. 19, 1647-9, (2009)

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Synthesis of potent antitumor and antiviral benzofuran derivatives. Shadia A Galal et al Bioorg. Med. Chem. Lett. 19, 2420-8, (2009)

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Design, synthesis and anticancer activities of hybrids of indole and barbituric acids--identification of highly promising leads. Palwinder Singh et al Bioorg. Med. Chem. Lett. 19, 3054-8, (2009)

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In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives. Julia K J Ahlskog et al Bioorg. Med. Chem. Lett. 19, 4851-6, (2009)

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Sesquiterpenoids from Pilea cavaleriei subsp. crenata. Gui-Hua Tang et al Bioorg. Med. Chem. Lett. 19, 5737-40, (2009)

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A facile synthesis and biological activity of novel tetrahydrobenzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-ones. Qingyun Ren et al Bioorg. Med. Chem. Lett. 19, 6713-6, (2009)

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Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents. Shi-Wu Chen et al Bioorg. Med. Chem. 17, 3111-7, (2009)

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Preparation of novel (Z)-4-ylidenebenzo[b]furo[3,2-d][1,3]oxazines and their biological activity. Yukako Tabuchi et al Bioorg. Med. Chem. 17, 3959-67, (2009)

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Synthesis, antitumor evaluation, molecular modeling and quantitative structure-activity relationship (QSAR) of some novel arylazopyrazolodiazine and triazine analogs. Ahmed El-Shafei et al Bioorg. Med. Chem. 17, 5096-105, (2009)

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Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines. Leticia G León et al Bioorg. Med. Chem. 17, 6251-6, (2009)

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Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity. Steffi Noll et al Eur. J. Med. Chem. 44, 1172-9, (2009)

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Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs. Abdulrahman M Al-Obaid et al Eur. J. Med. Chem. 44, 2379-91, (2009)

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Novel 2,4,5-trisubstituted oxazole derivatives: synthesis and antiproliferative activity. Xin-Hua Liu et al Eur. J. Med. Chem. 44, 3930-5, (2009)

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Novel modified steroid derivatives of androstanolone as chemotherapeutic anti-cancer agents. Mohamed El-Far et al Eur. J. Med. Chem. 44, 3936-46, (2009)

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Synthesis of substituted-phenyl-1,2,4-triazol-3-thione analogues with modified D-glucopyranosyl residues and their antiproliferative activities. Zhizhang Li et al Eur. J. Med. Chem. 44, 4716-20, (2009)

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Synthesis and anticancer activity of N-bis(trifluoromethyl)alkyl-N'-thiazolyl and N-bis(trifluoromethyl)alkyl-N'-benzothiazolyl ureas. Elena L Luzina et al Eur. J. Med. Chem. 44, 4944-53, (2009)

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A Ser29Leu substitution in the cytosine deaminase Fca1p is responsible for clade-specific flucytosine resistance in Candida dubliniensis. Brenda A McManus et al Antimicrob. Agents Chemother. 53, 4678-85, (2009)

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Pyrrolidinoindoline alkaloids from Selaginella moellendorfii. Yue-Hu Wang et al J. Nat. Prod. 72, 1151-4, (2009)

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Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line. Feng Li et al J. Nat. Prod. 72, 1283-7, (2009)

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Cycloaspeptides F and G, Cyclic Pentapeptides from a Cordyceps-colonizing isolate of Isaria farinosa. Yonggang Zhang et al J. Nat. Prod. 72, 1364-7, (2009)

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Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici. Ling Liu et al J. Nat. Prod. 72, 1482-6, (2009)

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Cytotoxic constituents of Soymida febrifuga from Myanmar. Suresh Awale et al J. Nat. Prod. 72, 1631-6, (2009)

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Allenyl and alkynyl phenyl ethers from the endolichenic fungus Neurospora terricola. Fan Zhang et al J. Nat. Prod. 72, 1782-5, (2009)

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Quassinoids from Eurycoma longifolia. Katsunori Miyake et al J. Nat. Prod. 72, 2135-40, (2009)

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Pyrrolidinones from the ascomycete fungus Albonectria rigidiuscula. Jian Li et al J. Nat. Prod. 72, 2184-7, (2009)

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2-Arylbenzofuran Derivatives from Morus cathayana. Gang Ni et al J. Nat. Prod. 72, 966-8, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. Ashley Jarvis et al J. Med. Chem. 53, 2215-26, (2010)

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A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity. He Huang et al J. Med. Chem. 53, 3048-64, (2010)

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Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. Menichincheri, M.; et al. J. Med. Chem. 53, 7296, (2010)

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Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti-tumor activity. Hai Ling Sun et al Bioorg. Med. Chem. Lett. 20, 1961-4, (2010)

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Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum. Abhishek Goswami et al Bioorg. Med. Chem. Lett. 20, 359-61, (2010)

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Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents X. Liu, et al., Bioorg. Med. Chem. Lett. 20, 4163-4167, (2010)

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Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents. Xin-Hua Liu et al Bioorg. Med. Chem. Lett. 20, 5705-8, (2010)

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Synthesis, X-ray crystal structure study and antitumoral evaluations of 5,6-disubstituted pyrimidine derivatives. Tatjana Gazivoda Kraljevi? et al Bioorg. Med. Chem. 18, 2704-12, (2010)

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Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Fatmah A M Al-Omary et al Bioorg. Med. Chem. 18, 2849-63, (2010)

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Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines. José C Aponte et al Bioorg. Med. Chem. 18, 2880-6, (2010)

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Aplysinopsin analogs: synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones Thirupathi R. Y.; et al. Bioorg. Med. Chem. 18, 3570, (2010)

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Novel nucleosides as potent influenza viral inhibitors. Manohar Sharma Vedula et al Bioorg. Med. Chem. 18, 6329-39, (2010)

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Effect of goniothalamin on the development of Ehrlich solid tumor in mice. Débora Barbosa Vendramini-Costa et al Bioorg. Med. Chem. 18, 6742-7, (2010)

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QSAR-based solubility model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 18, 7078-84, (2010)

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Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents. Qing-Zhong Zheng et al Bioorg. Med. Chem. 18, 7836-41, (2010)

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Synthesis and anticancer activity of new 1-[(5 or 6-substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives. Young Bok Lee et al Bioorg. Med. Chem. 18, 7966-74, (2010)

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Synthesis of 4?-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities. Ahmed Kamal et al Bioorg. Med. Chem. 18, 8493-500, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives and evaluation of their activities against human colon cancer cell lines. Saritha Jyostna Tangeda et al Eur. J. Med. Chem. 45, 1453-8, (2010)

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QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations. Andrey A Toropov et al Eur. J. Med. Chem. 45, 1639-47, (2010)

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Novel benzimidazole-pyrimidine conjugates as potent antitumor agents. Heba T Abdel-Mohsen et al Eur. J. Med. Chem. 45, 2336-44, (2010)

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Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones. Kanagasabai Kanagalakshmi et al Eur. J. Med. Chem. 45, 2447-52, (2010)

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Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: induction of actin disruption and tumor cell-selective toxicity. Hideaki Yamaguchi et al Eur. J. Med. Chem. 45, 2943-8, (2010)

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Synthesis and antitumor activity of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazolonucleoside analogues. Jin-Lan Yu et al Eur. J. Med. Chem. 45, 3219-22, (2010)

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Synthesis and antitumor activity of liquiritigenin thiosemicarbazone derivatives. Kun Hu et al Eur. J. Med. Chem. 45, 3453-8, (2010)

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Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives. Miguel Angel Vilchis-Reyes et al Eur. J. Med. Chem. 45, 379-86, (2010)

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Anticancer activity of N-bis(trifluoromethyl)alkyl-N'-(polychlorophenyl) and N'-(1,2,4-triazolyl) ureas. Elena L Luzina et al Eur. J. Med. Chem. 45, 5507-12, (2010)

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Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives. Sham M Sondhi et al Eur. J. Med. Chem. 45, 555-63, (2010)

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Synthesis, antitumor activity and molecular docking study of novel sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives. Mohsen M Kamel et al Eur. J. Med. Chem. 45, 572-80, (2010)

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Semi-synthesis and anti-tumor activity of 5,8-O-dimethyl acylshikonin derivatives. Wen Zhou et al Eur. J. Med. Chem. 45, 6005-11, (2010)

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Cytotoxic activity of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides. Tilak Raj et al Eur. J. Med. Chem. 45, 790-4, (2010)

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Triterpenoids and steroids from the fruits of Melia toosendan and their cytotoxic effects on two human cancer cell lines. Shi-Biao Wu et al J. Nat. Prod. 73, 1898-906, (2010)

---

Oxepinochromenones, furochromenone, and their putative precursors from the endolichenic fungus Coniochaeta sp. Yinchao Wang et al J. Nat. Prod. 73, 920-4, (2010)

---

Antiproliferative activity of withanolides against human breast cancer cell lines. Rubén P Machin et al J. Nat. Prod. 73, 966-8, (2010)

---

A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

---

3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins. Umashankar Das et al J. Med. Chem. 54, 3445-9, (2011)

---

N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase II? and induce apoptosis in G1/S phase. Ashish T Baviskar et al J. Med. Chem. 54, 5013-30, (2011)

---

Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas. Hao Peng et al Bioorg. Med. Chem. Lett. 21, 1102-4, (2011)

---

Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents. Xin-Hua Liu et al Bioorg. Med. Chem. Lett. 21, 2916-20, (2011)

---

Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins. Pardeep Singh et al Bioorg. Med. Chem. Lett. 21, 3017-20, (2011)

---

Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates. Xiao-Juan Wang et al Bioorg. Med. Chem. Lett. 21, 3074-7, (2011)

---

Synthesis and anti-tumor activity of novel ethyl 3-aryl-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates. Tiantian Wang et al Bioorg. Med. Chem. Lett. 21, 3381-3, (2011)

---

Antiproliferative and apoptotic sesquiterpene lactones from Carpesium faberi. Xu-Wen Li et al Bioorg. Med. Chem. Lett. 21, 366-72, (2011)

---

Synthesis and cytotoxicity of 8-cyano-3-substitutedalkyl-5-methyl-4-methylene-7-methoxy-3,4-dihydropyrido[4,3-d]pyrimidines. Wen-Yan Mo et al Bioorg. Med. Chem. Lett. 21, 5975-7, (2011)

---

Synthesis, biological evaluation and molecular docking studies of 1,3,4-thiadiazole derivatives containing 1,4-benzodioxan as potential antitumor agents. Juan Sun et al Bioorg. Med. Chem. Lett. 21, 6116-21, (2011)

---

Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents. Kamal, A.; et al. Bioorg. Med. Chem. 19, 2975, (2011)

---

Selective bone targeting 5-fluorouracil prodrugs: synthesis and preliminary biological evaluation. Liang Ouyang et al Bioorg. Med. Chem. 19, 3750-6, (2011)

---

New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities. Takeshi Yamada et al Bioorg. Med. Chem. 19, 4106-13, (2011)

---

Antifungal thiopeptide cyclothiazomycin B1 exhibits growth inhibition accompanying morphological changes via binding to fungal cell wall chitin. Naoko Mizuhara et al Bioorg. Med. Chem. 19, 5300-10, (2011)

---

Synthesis and antitumor activity of ?-carboline 3-(substituted-carbohydrazide) derivatives. Valéria Aquilino Barbosa et al Bioorg. Med. Chem. 19, 6400-8, (2011)

---

Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents. Xiao-Min Zhang et al Bioorg. Med. Chem. 19, 6518-24, (2011)

---

2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers. Ahmed Kamal et al Bioorg. Med. Chem. 19, 7136-50, (2011)

---

Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. Bakr F Abdel-Wahab et al Eur. J. Med. Chem. 46, 1505-11, (2011)

---

Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma. Seif-Eldin N Ayyad et al Eur. J. Med. Chem. 46, 175-82, (2011)

---

Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents. Subhas S Karki et al Eur. J. Med. Chem. 46, 2109-16, (2011)

---

Synthesis and in vitro anti-tumor activity of new oxadiazole thioglycosides. M A Abu-Zaied et al Eur. J. Med. Chem. 46, 229-35, (2011)

---

New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine. Luisa C López-Cara et al Eur. J. Med. Chem. 46, 249-58, (2011)

---

Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: synthesis, antiproliferative activity and DNA binding studies. Marijana Hranjec et al Eur. J. Med. Chem. 46, 2748-58, (2011)

---

Design, synthesis and in vitro drug release investigation of new potential 5-FU prodrugs. Pierre Daumar et al Eur. J. Med. Chem. 46, 2867-79, (2011)

---

Synthesis, antitumor and antimicrobial activities of 4-(4-chlorophenyl)-3-cyano-2-(?-O-glycosyloxy)-6-(thien-2-yl)-nicotinonitrile. Hassan A El-Sayed et al Eur. J. Med. Chem. 46, 2948-54, (2011)

---

Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa. Andrea Chicca et al Eur. J. Med. Chem. 46, 3066-70, (2011)

---

Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents. Doma Mahendhar Reddy et al Eur. J. Med. Chem. 46, 3210-7, (2011)

---

Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives. Wen Zhou et al Eur. J. Med. Chem. 46, 3420-7, (2011)

---

Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2-a]pyrimidines. Nadia S El-Sayed et al Eur. J. Med. Chem. 46, 3714-20, (2011)

---

Anticancer activity and cDNA microarray studies of a (RS)-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl]-6-chloro-9H-purine, and an acyclic (RS)-O,N-acetalic 6-chloro-7H-purine. Octavio Caba et al Eur. J. Med. Chem. 46, 3802-9, (2011)

---

Synthesis, biological evaluation of chrysin derivatives as potential immunosuppressive agents. Peng-Cheng Lv et al Eur. J. Med. Chem. 46, 393-8, (2011)

---

Synthesis and antitumour activity of ?-hydroxyisovalerylshikonin analogues. Zhen Rao et al Eur. J. Med. Chem. 46, 3934-41, (2011)

---

Synthesis and antitumor activity of ureas containing pyrimidinyl group. Chuanfei Jin et al Eur. J. Med. Chem. 46, 429-32, (2011)

---

Branched-chain C-cyano pyranonucleosides: synthesis of 3'-C-cyano & 3'-C-cyano-3'-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents. Christos Kiritsis et al Eur. J. Med. Chem. 46, 5668-74, (2011)

---

Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives. Datong Zhang et al Eur. J. Med. Chem. 46, 5868-77, (2011)

---

Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation. Aurélien Montagu et al Eur. J. Med. Chem. 46, 778-86, (2011)

---

Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives. Wukun Liu et al Eur. J. Med. Chem. 46, 907-13, (2011)

---

Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase. Niki Tzioumaki et al Eur. J. Med. Chem. 46, 993-1005, (2011)

---

Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44. Chun-Shun Li et al J. Nat. Prod. 74, 1331-4, (2011)

---

Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos. Takashi Kikuchi et al J. Nat. Prod. 74, 137-44, (2011)

---

Nigerapyrones A-H, ?-pyrone derivatives from the marine mangrove-derived endophytic fungus Aspergillus niger MA-132. Dong Liu et al J. Nat. Prod. 74, 1787-91, (2011)

---

Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa. Yong Chen et al J. Nat. Prod. 74, 2477-81, (2011)

---

Comazaphilones A-F, azaphilone derivatives from the marine sediment-derived fungus Penicillium commune QSD-17. Shu-Shan Gao et al J. Nat. Prod. 74, 256-61, (2011)

---

Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem). Takashi Kikuchi et al J. Nat. Prod. 74, 866-70, (2011)

---

Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

---

Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivatives. Tatjana Gazivoda Kraljevi? et al Bioorg. Med. Chem. Lett. 22, 308-12, (2012)

---

Acyl derivatives of boswellic acids as inhibitors of NF-?B and STATs. Ajay Kumar et al Bioorg. Med. Chem. Lett. 22, 431-5, (2012)

---

Synthesis and in vitro antiproliferative evaluation of pyrimido[5,4-c]quinoline-4-(3H)-one derivatives. Yong Ai et al Eur. J. Med. Chem. 47, 206-13, (2012)

---

Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin. Li-Ming Zhao et al Eur. J. Med. Chem. 47, 255-60, (2012)

---

Novel 1,3,4-heterodiazole analogues: synthesis and in-vitro antitumor activity. Azza T Taher et al Eur. J. Med. Chem. 47, 445-51, (2012)

---

1,2,3-Triazole tethered ?-lactam-Chalcone bifunctional hybrids: synthesis and anticancer evaluation. Pardeep Singh et al Eur. J. Med. Chem. 47, 594-600, (2012)

---

Substituted thiazoles V. synthesis and antitumor activity of novel thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine analogues. Fatmah A M Al-Omary et al Eur. J. Med. Chem. 47, 65-72, (2012)

---

Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. Sandeep Kumar Sharma et al Eur. J. Med. Chem. 48, 16-25, (2012)

---

Synthesis and antitumor evaluation of some new 1,3,4-oxadiazole-based heterocycles. Samir Bondock et al Eur. J. Med. Chem. 48, 192-9, (2012)

---

Synthesis and cytotoxicity of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates. Lihong Ning et al Eur. J. Med. Chem. 48, 379-84, (2012)

---

Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity. Yikai Zhang et al Eur. J. Med. Chem. 48, 69-80, (2012)

---

Synthesis and evaluation of anticancer activity of some novel 6-aryl-2-(p-sulfamylphenyl)-pyridazin-3(2H)-ones. I G Rathish et al Eur. J. Med. Chem. 49C, 304-9, (2012)

---

Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. Wen-Ting Huang et al Eur. J. Med. Chem. 49C, 48-54, (2012)

---

Bakuchiol derivatives as novel and potent cytotoxic agents: A report. Rabiya Majeed et al Eur. J. Med. Chem. 49C, 55-67, (2012)

---

Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells. Catherine H Kaschula et al Eur. J. Med. Chem. 50, 236-54, (2012)

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Merck 14,4181

Beil. 24,IV,1229

Aldrich MSDS 1, 978:A / Corp MSDS 1 (1), 1731:B / FT-IR 1 (2), 809:D / FT-IR 2 (3), 3829:C / FT-NMR 1 (3), 362:C / IR-Spectra (3), 1353:H / IR-Spectra (2), 1179:B / NMR-Reference 2 (2), 690:D / RegBook 1 (2), 2565:C / Sax 6, 1449 / Sigma FT-IR 1 (1), 996:C / Structure Index 1, 405:D:4