F6627 Sigma


≥99% (HPLC), powder

Synonym: 2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione


Related Categories Antitumor Agents, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cancer Research, Cell Biology,
assay   ≥99% (HPLC)
form   powder
color   white
mp   282-286 °C (dec.)(lit.)
solubility   1 M NH4OH: soluble
  DMSO/DMF: soluble
  methanol: soluble
Gene Information   human ... TYMS(7298)


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Biochem/physiol Actions

A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.


1, 5, 10 g in glass bottle

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