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F6754 Sigma

Ferritin from human liver

Type IV, 10 μg/mL

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Properties

Related Categories Antioxidants and Cytoprotectants, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress More...
sterility   0.2 μm filtered
type   Type IV
mol wt   H subunit mol wt ~21 kDa
  L subunit mol wt ~19 kDa
  mol wt ~440 kDa (a shell of 24 protein subunits (apoferritin) and a core of Fe3+ ions)
packaging   vial of 2 μg
concentration   10 μg/mL
storage temp.   2-8°C
Gene Information   human ... FTH1(2495), FTL(2512), FTMT(94033)

Description

Physical form

Solution in 10 mM Tris, 150 mM NaCl, pH 8.0, and 0.1% sodium azide.

Application

Ferritin is an iron storage protein that plays a central role in iron metabolism, and may be elevated in inflammatory or malignant diseases. It has been used in studies as an indicator of body iron supply, but may prove inaccurate in the presence of chronic inflammation.

Biochem/physiol Actions

A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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