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F6771 - Fumagillin from Aspergillus fumigatus

F6771 Sigma

Fumagillin from Aspergillus fumigatus

≥90%, powder

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CAS Number 23110-15-8
Empirical Formula (Hill Notation) C₂₆H₃₄O₇
Molecular Weight 458.54
EC Number 245-433-8
MDL number MFCD03990453
PubChem Substance ID 24894920
Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF)

Fumagillin from Aspergillus fumigatus ≥90%, powder

Properties

Related Categories	Angiogenesis, Angiogenesis Inhibitors, Angiogenesis Regulators, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiparasitic / Antiprotozoal / Anthelminthic, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, ECM Related Proteins and Peptides, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Extracellular Matrix, F, Interferes with DNA Synthesis, L to O, Matrix Metalloproteinases Products, Mechanism of Action, Methionine Aminopeptidase-2, Spectrum of Activity More...
assay	≥90%
form	powder
color	white
solubility	ethanol: soluble1 mg/mL
storage temp.	−20°C

Description

Biochem/physiol Actions

Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.

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Related Papers

Suppression of hepatoma growth and angiogenesis by a fumagillin derivative TNP470: possible involvement of nitric oxide synthase. Yoshida, J., et al. Cancer Res. 58, 3751-3756, (1998)

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