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F6926 Sigma

Fibroblast Growth Factor-8b from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: FGF-8b

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Description

Analysis Note

The biological activity is measured by its ability to stimulate proliferation of NR6R-3T3 fibroblasts.

Packaging

25 μg in glass bottle

Physical form

Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS, 50 mM sodium sulfate (pH 7.2) containing 50 μg of bovine serum albumin per 1 μg of cytokine.

Application

Fibroblast Growth Factor-8b from mouse has been used-
• for subgerminal cavity injection in fertilized quail, chicken, turtle and emu eggs
• in the induction of neural differentiation in stem cells from Human Exfoliated Deciduous teeth (SHED) and
• in experiments conducted on fertilized hens′ eggs, where FGF8 induced SOX3 gene.

Biochem/physiol Actions

FGF-8b is involved in ectodermal differentiation in the post-gastrulation embryo, including outgrowth and patterning of the face, limbs, and central nervous system. FGF-8b activates the "c" splice form of FGFR-2, FGFR-3, and FGFR-4.

Fibroblast growth factor 8b (FGF8b) isoform of FGF8 has the most potent angiogenic and tumorigenic properties. In prostate cancer, it is responsible for angiogenesis, tumorigenesis and invasion. Exogenous expression of this gene in prostate epithelium leads to prostatic intraepithelial neoplasia (PIN). It also interacts with pattern recognition receptor long pentraxin-3 (PTX3), which is involved in local inflammation.

General description

Fibroblast growth factor 8 (FGF8) is a member of the FGF family, and was initially cloned from androgen-dependent mouse mammary carcinoma cell line. Alternative splicing of this gene produces four different isoforms mainly, FGF8a, FGF8b, FGF8e and FGF8f.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Fibroblast Growth Factor Family (FGF)

Fibroblast Growth Factors (FGFs) are potent regulators of cell proliferation, differentiation and function and are critically important in normal development, tissue maintenance, wound repair and ang...
Keywords: Angiogenesis, Cancer, Cardiovascular, Cell proliferation, Diabetes, Diseases, Gene expression, Growth factors, Ligands

Peer-Reviewed Papers
15

References

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