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F7129 Sigma

5-Fluorocytosine

nucleoside analog

Synonym: 4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal, Biochemicals and Reagents,
InChI Key   XRECTZIEBJDKEO-UHFFFAOYSA-N
assay   ≥99% (TLC)
mp   298-300 °C (dec.)(lit.)
Mode of action   DNA synthesis | interferes
  protein synthesis | interferes
antibiotic activity spectrum   fungi
storage temp.   2-8°C

Description

Application

Used in studies on TMP biosynthesis.

Biochem/physiol Actions

Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.

Packaging

1, 5 g in poly bottle

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
HA6040000
Protocols & Articles

Articles

Antifungals

Antifungal compounds have been overshadowed by antibacterials in research interest and application due to the greater impact bacterial infections have had on health. Resistance to antibacterial drugs...
Chloe McClanahan
BioFiles 2009, 4.3, 10.
Keywords: Antibiotics, Antifungals, Cellular processes, Clinical, Fungicides, Gene expression, Research Reports, Transcription

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Peer-Reviewed Papers
15

References

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