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F7176 Sigma

Fibroblast Growth Factor-17 human

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: FGF-17

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Description

Analysis Note

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in NR6R-3T3 fibroblasts.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.

Biochem/physiol Actions

FGF-17 is a heparin binding growth factor preferentially expressed in embryonic brain. It is 60% identical to FGF-8 and 50% identical to FGF-18.

FGF17 (fibroblast growth factor 17) acts as a ligand for gonadotropin-releasing hormone (GnRH), which functions in neuron ontogeny. Mutations in this gene are also associated with congenital hypogonadotropic hypogonadism (CHH). Temporal and spatial gradients of this protein are responsible for the control of differentiation and proliferation of midline cerebrum.

General description

FGF17 (fibroblast growth factor 17) is a member of the secreted protein family called FGF. It is highly homologous to FGF8. Along with FGF18, it is a member of the FGF8 subfamily. It is expressed in midbrain-hindbrain (MHB) junction.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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