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F7426 Sigma

Flt-3/Fc Chimera human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: fms-like Tyrosine Kinase, Fetal Liver Kinase (Flk-2), Stem Cell Tyrosine Kinase (Stk-1)

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Description

Analysis Note

The biological activty is measured by its ability to inhibit recombinant human Flt-3 ligand-induced proliferation of a Flt-3 transfected pro-B cell line.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Biochem/physiol Actions

FLT3 (fms-related tyrosine kinase 3), upon interaction with its ligand, undergoes conformational changes to form homodimers. This results in phosphorylation of FLT3 and activation of downstream signaling pathways including phosphatidylinositol 3-kinase (PI3K/AKT), mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and signal transducer and activator of transcription 5 (STAT5) pathways. Internal tandem duplication (ITD) mutation or a point mutation in juxtamembrane domain-coding region or within the activation loop domain, respectively, of this gene lead to its constitutive action. FLT3/ITD mutation is associated with later stages of acute myeloid leukemia (AML) pathogenesis. These patients have poor prognosis.

Member of the class III subfamily of receptor tyrosine kinases that also includes KIT and FMS. Involved in the regulation of growth in hematopoietic stem cells.

General description

FLT3 (fms-related tyrosine kinase 3) is a tyrosine kinase receptor and the gene is localized to human chromosome 13q12. The encoded protein is composed of 993 amino acids, and consists of five immunoglobulin (Ig)-like domains in its exoplasmic region. It is also composed of a transmembrane region, a juxtamembrane domain, and two tyrosine kinase domains in its intracellular domain. The tyrosine kinase domains are linked by a kinase-insert domain.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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