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F7551 Sigma

Fractalkine, Extracellular Domain from mouse

>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Synonym: CX3CL-1, Neurotactin

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
recombinant   expressed in baculovirus infected Sf21 cells
assay   >97% (SDS-PAGE)
form   lyophilized powder
mol wt   calculated mol wt 34 kDa
  mol wt ~90 kDa by SDS-PAGE
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Cx3cl1(20312)

Description

Analysis Note

The biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes.

Other Notes

Extracellular domain (amino acids 1-337) fused to a 6X histidine tag at the C-terminus.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg of bovine serum albumin.

Biochem/physiol Actions

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)–dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease. In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.

Recombinant extracellular fractalkine simulates the shed form of the chemokine and chemoattracts neutrophils and T cells.

General description

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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