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F7805 Sigma

FER (542-end), active, GST tagged from mouse

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: AV062135, C330004K01 Rik, Fert2, Fert



Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   557-753 nmol/min·mg
mol wt   mol wt ~59 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   mouse ... Fert2(14158)


Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

In fibroblasts, FER acts downstream of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) receptors. It is also activated downstream of FcγRI, a high-affinity receptor for immunoglobulin E (IgE), in mast cells. However, the exact role in these pathways is yet unknown. Inactivation of this protein in mice results in reduction in cortactin phosphorylation, though they are viable and fertile. Thus, Fer might be involved in controlling cell growth, adhesion, development of retina and spermatogenesis. It is essential for the phosphorylation of cortactin.

General description

FER is a nonreceptor protein-tyrosine kinase (PTK), which has a ubiquitous expression pattern. Along with Fps/Fes protein, it makes up the subfamily called PTK. It contains three predicted coiled-coil (CC) motifs in its N-terminal, a Src homology 2 (SH2) domain located in the center, and a catalytic domain at its C-terminal. An isoform of this protein is specific to the testis, and is called FerT.

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