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Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon’ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).
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Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21. Wang, X., et al. Mutat. Res. 551, 167-80, (2004)
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination Vedadi, M., et al. Proc. Natl. Acad. Sci. U. S. A. 103, 15835-40, (2006)
Molecular analysis of a UDP-GlcNAc:polypeptide alpha-N-acetylglucosaminyltransferase implicated in the initiation of mucin-type O-glycosylation in Trypanosoma cruzi. Heise N Glycobiology 19(8), 918-33, (2009)
A decreased micronucleus frequency in human lymphocytes after folate and vitamin B12 intervention: a preliminary study in a Yunnan population. Ni J, Liang Z, Zhou T, et al. Int. J. Vitam. Nutr. Res. 82(6), 374-82, (2012)
Folate grafted Prussian Blue entrapped with gadolinium(III) as a new contrast agent for tumor-targeted magnetic resonant imaging. Song XX, Liu ZJ, and Tang Q J. Nanosci. Nanotechnol. 13(8), 5233-9, (2013)
Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters. McNulty B, McNulty H, Marshall B, et al. Am. J. Clin. Nutr. 98(1), 92-8, (2013)
β,β-carotene 15,15'-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells. Pham DN, Leclerc D, Lévesque N, et al. Am. J. Clin. Nutr. 98(2), 413-22, (2013)
Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana. Wei Z, Sun K, Sandoval FJ, et al. Arch. Biochem. Biophys. 536(1), 87-96, (2013)
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