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F7876 Sigma

Folic acid

≥97%

Synonym: PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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Description

Packaging

1, 10, 25, 100 g in glass bottle

Biochem/physiol Actions

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon’ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Price and Availability

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TruPAGE™ Pre-cast Polyacrylamide Gels


TruPAGE™ Pre-cast Polyacrylamide GelsTruPAGE Gels run true every time!

  • . 2-Year Shelf Life
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Metabolomic Pathways Chart

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BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

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meets USP testing specifications

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tested according to Ph.Eur.

Tetrahydrofolic acid

≥65% (when packaged), powder

Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
LP5425000

Protocols & Articles

Articles

Determination of Water Content in Folic Acid Using Karl Fischer Titration

The determination of water in carboxylic acids is usually straightforward provided the substances are soluble. Strong acids must be neutralized. Acetic acid and related compounds have a tendency to u...
Keywords: Esterifications, Pharmaceutical, Titrations

Peer-Reviewed Papers

References

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Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination Vedadi, M., et al. Proc. Natl. Acad. Sci. U. S. A. 103, 15835-40, (2006)

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Dictyostelium discoideum: a model host to measure bacterial virulence. Froquet, R., et al. Nat. Protoc. 4, 25-30, (2009)

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Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes. Lindberg, H.K., et al. Mutat. Res. 617, 33-45, (2007)

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Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21. Wang, X., et al. Mutat. Res. 551, 167-80, (2004)

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Inhibitors of de novo folate enzymes in Plasmodium falciparum. Nzila A. Drug Discov. Today 11, 939-944, (2006)

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Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury. Szczypka, M.S., et al. Stem Cells 23, 44-54, (2005)

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Dihydrofolate reductase as a target for chemotherapy in parasites. Gangjee A, Kurup S, Namjoshi O. Curr. Pharm. Des. 13, 609-639, (2007)

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Regulation of human dihydrofolate reductase activity and expression. Abali EE, Skacel NE, Celikkaya H, Hsieh YC. Vitam. Horm. 79, 267-292, (2008)

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PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer. Naumann RW, Coleman RL, Burger RA, et al. J. Clin. Oncol. 31(35), 4400-6, (2013)

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Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent β--emitters: in vitro and in vivo study of a 44Sc-DOTA-folate conjugate. Müller C, Bunka M, Reber J, et al. J. Nucl. Med. 54(12), 2168-74, (2013)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. Grarup N, Sulem P, Sandholt CH, et al. PLoS Genet. 9(6), e1003530, (2013)

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A domino effect in antifolate drug action in Escherichia coli. Yun Kyung Kwon et al Nat. Chem. Biol. 4, 602-8, (2008)

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Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters. McNulty B, McNulty H, Marshall B, et al. Am. J. Clin. Nutr. 98(1), 92-8, (2013)

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Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate. de Rotte MC, de Jong PH, Pluijm SM, et al. Arthritis Rheum. 65(11), 2803-13, (2013)

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In situ enrichment of folate by microorganisms in beta-glucan rich oat and barley matrices. Kariluoto S, Edelmann M, Nyström L, et al. Int. J. Food Microbiol. 176, 38-48, (2014)

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β,β-carotene 15,15'-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells. Pham DN, Leclerc D, Lévesque N, et al. Am. J. Clin. Nutr. 98(2), 413-22, (2013)

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Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase. Tihomir Tomasi? et al Bioorg. Med. Chem. Lett. 19, 153-7, (2009)

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The impact of lipid-based nutrient supplement provision to pregnant women on newborn size in rural Malawi: a randomized controlled trial. Ashorn P, Alho L, Ashorn U, et al. Am. J. Clin. Nutr. 101(2), 387-97, (2015)

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Complementary feeding recommendations based on locally available foods in Indonesia. Fahmida U, Santika O, Kolopaking R, et al. Food Nutr. Bull. 35(4 Suppl), S174-9, (2014)

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Supplement use and other characteristics among pregnant women with a previous pregnancy affected by a neural tube defect - United States, 1997-2009. Arth A, Tinker S, Moore C, et al. MMWR Morb. Mortal. Wkly. Rep. 64(1), 6-9, (2015)

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Updated estimates of neural tube defects prevented by mandatory folic Acid fortification - United States, 1995-2011. Williams J, Mai CT, Mulinare J, et al. MMWR Morb. Mortal. Wkly. Rep. 64(1), 1-5, (2015)

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Effect of maternal multiple micronutrient vs iron-folic acid supplementation on infant mortality and adverse birth outcomes in rural Bangladesh: the JiVitA-3 randomized trial. West KP, Shamim AA, Mehra S, et al. JAMA 312(24), 2649-58, (2014)

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Maternal folate status, but not that of vitamins B-12 or B-6, is associated with gestational age and preterm birth risk in a multiethnic Asian population. Chen LW, Lim AL, Colega M, et al. J. Nutr. 145(1), 113-20, (2015)

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Derivation and validation of homocysteine score in u.s. Men and women. Jung S, Je Y, Giovannucci EL, et al. J. Nutr. 145(1), 96-104, (2015)

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Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations. Bird JK, Ronnenberg AG, Choi SW, et al. J. Nutr. 145(1), 79-86, (2015)

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Dietary folate intake and breast cancer risk: European prospective investigation into cancer and nutrition. de Batlle J, Ferrari P, Chajes V, et al. J. Natl. Cancer Inst. 107(1), 367, (2015)

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Growth and nutrition in children with food allergy requiring amino acid-based nutritional formulas. Robbins KA, Guerrerio AL, Hauck SA, et al. J. Allergy Clin. Immunol. 134(6), 1463-1466.e5, (2014)

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Bioavailability of enteric-coated microencapsulated calcium during pregnancy: a randomized crossover trial in Bangladesh. Roth DE, Pezzack B, Al Mahmud A, et al. Am. J. Clin. Nutr. 100(6), 1587-95, (2014)

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Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. van Wijngaarden JP, Swart KM, Enneman AW, et al. Am. J. Clin. Nutr. 100(6), 1578-86, (2014)

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Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region. Nishihara R, Wang M, Qian ZR, et al. Am. J. Clin. Nutr. 100(6), 1479-88, (2014)

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Preconception serum 1,1,1-trichloro-2,2,bis(p-chlorophenyl)ethane and B-vitamin status: independent and joint effects on women's reproductive outcomes. Ouyang F, Longnecker MP, Venners SA, et al. Am. J. Clin. Nutr. 100(6), 1470-8, (2014)

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Low serum vitamin B-12 and folate concentrations and low thiamin and riboflavin intakes are inversely associated with greater adiposity in Mexican American children. Gunanti IR, Marks GC, Al-Mamun A, et al. J. Nutr. 144(12), 2027-33, (2014)

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Results of 2-year vitamin B treatment on cognitive performance: secondary data from an RCT. van der Zwaluw NL, Dhonukshe-Rutten RA, van Wijngaarden JP, et al. Neurology 83(23), 2158-66, (2014)

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Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival. Johansson M, Fanidi A, Muller DC, et al. J. Natl. Cancer Inst. 106(12), doi:10.1093/jnci/dju327, (2014)

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Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. Zhang D, Sun X, Liu J, et al. Arterioscler. Thromb. Vasc. Biol. 35(1), 71-8, (2015)

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Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues. Llanos AA, Dumitrescu RG, Brasky TM, et al. Carcinogenesis 36(1), 60-7, (2015)

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SPADE, a new statistical program to estimate habitual dietary intake from multiple food sources and dietary supplements. Dekkers AL, Verkaik-Kloosterman J, van Rossum CT, et al. J. Nutr. 144(12), 2083-91, (2014)

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The direction of the difference between Canadian and American erythrocyte folate concentrations is dependent on the assay method employed: a comparison of the Canadian Health Measures Survey and National Health and Nutrition Examination Survey. Colapinto CK, Tremblay MS, Aufreiter S, et al. Br. J. Nutr. 112(11), 1873-81, (2014)

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Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to in vitro fertilization pregnancy outcome. Murto T, Kallak TK, Hoas A, et al. Acta Obstet. Gynecol. Scand. 94(1), 65-71, (2015)

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Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm. Siu KL and Cai H Am. J. Physiol. Heart Circ. Physiol. 307(11), H1559-64, (2014)

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Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B 12 intakes. Jiang-Hua Q, De-Chuang J, Zhen-Duo L, et al. Tumour Biol. 35(12), 11895-901, (2014)

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Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate. Funk RS, van Haandel L, Leeder JS, et al. Arthritis Rheumatology 66(12), 3476-85, (2014)

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Folate intake and the risk of oral cavity and pharyngeal cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology Consortium. Galeone C, Edefonti V, Parpinel M, et al. Int. J. Cancer 136(4), 904-14, (2015)

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[Pregnancy again? The importance of folic acid]. Poulin-Chartrand S Perspect. Infirm. 11(3), 10, (2014)

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How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy. Jennings BA and Willis G Cancer Lett. 356(2 Pt A), 224-30, (2015)

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[Kinetic pattern of folic acid release from polyurethane matrices of varied structures]. Hryhor'ieva MV Ukr. Biokhim. Zh. 85(5), 149-53, (2013)

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[The importance of folic acid deficiency in the pathogenesis of vascular, mixed and Alzheimer's disease dementia]. Marzena Z and Jerzy L Pol. Merkur. Lekarski 35(208), 205-9, (2013)

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Bioavailability of iron, zinc, folic acid, and vitamin A from fortified maize. Moretti D, Biebinger R, Bruins MJ, et al. Ann. N. Y. Acad. Sci. 1312, 54-65, (2014)

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Folic acid or folinic acid for reducing side effects of methotrexate for people with rheumatoid arthritis. Shea B J. Evid. Based. Med. 6(3), 202-3, (2013)

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[Vitamin B9]. Guilland JC and Aimone-Gastin I Rev. Prat. 63(8), 1079, 1081-4, (2013)

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Nutritional requirements in pregnancy and use of dietary supplements. Williamson C and Wyness L Community Pract. 86(8), 44-7, (2013)

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[DGE releases new reference values for folate]. Kinderkrankenschwester 32(7), 277, (2013)

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Intakes of folic acid from dietary supplements and fortified products in students. Sicińska E and Bojarska K Rocz. Panstw. Zakl. Hig. 64(1), 55-9, (2013)

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[Nutrition and periodontal diseases]. Kantorowicz M, Chomyszyn-Gajewska M, Olszewska-Czyz I, et al. Prz. Lek. 70(1), 28-30, (2013)

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[Development of the high-throughput fluorescence assay detecting SNPs in hemostasis and folate metabolism genes for clinical use]. Prasolova MA, Shchepotina EG, and Dymshits GM Mol. Gen. Mikrobiol. Virusol. (1), 34-40, (2013)

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Effect of folic acid, vitamin B6 and vitamin B12 supplementation on mortality and cardiovascular complication among patients with chronic kidney disease: an evidence-based case report. Nursalim A, Siregar P, and Widyahening IS Acta Med. Indones. 45(2), 150-6, (2013)

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[Vitamins and minerals - supplementation with mass]. Oberpichler-Schwenk H Med. Monatsschr. Pharm. 36(5), 169, (2013)

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[Does 5-methyltetrahydrofolate offer any advantage over folic acid?]. Leemans L J. Pharm. Belg. (4), 16-22, (2012)

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[Folic acid metabolism gene polymorphism and congenital heart disease]. Wang BJ and Chen Y Zhonghua Er Ke Za Zhi. 50(8), 630-3, (2012)

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Spectrophotometric determination of drugs with iodine. Karuna T, et al. J. Sci. Ind. Res. 65(10), 808, (2006)

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Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Devalia V, Hamilton MS, and Molloy AM Br. J. Haematol. 166(4), 496-513, (2014)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Targeting and inhibition of cell growth by an engineered dendritic nanodevice. Thommey P Thomas et al J. Med. Chem. 48, 3729-35, (2005)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Neural tube defects: recent advances, unsolved questions, and controversies. Copp AJ, Stanier P, and Greene ND Lancet Neurol. 12(8), 799-810, (2013)

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Expression of functional folate receptors by human parathyroid cells. Weber CJ, Müller S, Safley SA, et al. Surgery 154(6), 1385-93; discussion 1393, (2013)

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Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis. Crider KS, Cordero AM, Qi YP, et al. Am. J. Clin. Nutr. 98(5), 1272-81, (2013)

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BP, cardiovascular disease, and death in the Folic Acid for Vascular Outcome Reduction in Transplantation trial. Carpenter MA, John A, Weir MR, et al. J. Am. Soc. Nephrol. 25(7), 1554-62, (2014)

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Cell uptake enhancement of folate targeted polymer coated magnetic nanoparticles. Licciardi M, Scialabba C, Cavallaro G, et al. J. Biomed. Nanotechnol. 9(6), 949-64, (2013)

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Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes. Lassi ZS, Salam RA, Haider BA, et al. Cochrane Database Syst. Rev. 3, CD006896, (2013)

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The role of folic acid fortification in neural tube defects: a review. Osterhues A, Ali NS, and Michels KB Crit. Rev. Food Sci. Nutr 53(11), 1180-90, (2013)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Neural tube defects, folic acid and methylation. Imbard A, Benoist JF, and Blom HJ Int. J. Environ. Res. Public Health 10(9), 4352-89, (2013)

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Vitamin B12, folic acid, and bone. Swart KM, van Schoor NM, and Lips P Curr. Osteoporos. Rep. 11(3), 213-8, (2013)

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Association of folic acid supplementation during pregnancy and infant bronchiolitis. Veeranki SP, Gebretsadik T, Dorris SL, et al. Am. J. Epidemiol. 179(8), 938-46, (2014)

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Biomarker responses to folic acid intervention in healthy adults: a meta-analysis of randomized controlled trials. Duffy ME, Hoey L, Hughes CF, et al. Am. J. Clin. Nutr. 99(1), 96-106, (2014)

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Imaging the folate receptor on cancer cells with 99mTc-etarfolatide: properties, clinical use, and future potential of folate receptor imaging. Maurer AH, Elsinga P, Fanti S, et al. J. Nucl. Med. 55(5), 701-4, (2014)

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Folate and B12 in prostate cancer. Collin SM Adv. Clin. Chem. 60, 1-63, (2013)

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Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran. Monfared A, Azimi SZ, Kazemnezhad E, et al. Transplantation 98(1), 66-71, (2014)

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Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice. Zhao M, Chen YH, Chen X, et al. Toxicol. Lett. 224(2), 201-8, (2014)

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Folic acid supplementation and cancer risk: a meta-analysis of randomized controlled trials. Qin X, Cui Y, Shen L, et al. Int. J. Cancer 133(5), 1033-41, (2013)

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Tubular overexpression of gremlin induces renal damage susceptibility in mice. Droguett A, Krall P, Burgos ME, et al. PLoS ONE 9(7), e101879, (2014)

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Gene delivery with active targeting to ovarian cancer cells mediated by folate receptor alpha. He Z, Yu Y, Zhang Y, et al. J. Biomed. Nanotechnol. 9(5), 833-44, (2013)

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Estimation of serum and erythrocyte folate concentrations in the New Zealand adult population within a background of voluntary folic acid fortification. Bradbury KE, Williams SM, Mann JI, et al. J. Nutr. 144(1), 68-74, (2014)

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Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects. Mills JL, Fan R, Brody LC, et al. Am. J. Clin. Nutr. 100(4), 1069-74, (2014)

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Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy. Liat Binyamin et al J. Immunol. 180, 6392-401, (2009)

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Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects. Czeizel AE, Dudás I, Vereczkey A, et al. Nutrients 5(11), 4760-75, (2013)

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Cobalamin C defect presenting with isolated pulmonary hypertension. Iodice FG, Di Chiara L, Boenzi S, et al. Pediatrics 132(1), e248-51, (2013)

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Fortification of corn masa flour with folic acid in the United States: an overview of the evidence. Hamner HC and Tinker SC Ann. N. Y. Acad. Sci. 1312, 8-14, (2014)

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Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Tedeschi PM, Markert EK, Gounder M, et al. Cell Death Dis. 4, e877, (2013)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. Schisterman EF, Silver RM, Lesher LL, et al. Lancet 384(9937), 29-36, (2014)

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QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES. A A Toropov et al Eur. J. Med. Chem. 43, 714-40, (2008)

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The effect of folate supplementation on methotrexate efficacy and toxicity in psoriasis patients and folic acid use by dermatologists in the USA. Al-Dabagh A, Davis SA, Kinney MA, et al. Am. J. Clin. Dermatol. 14(3), 155-61, (2013)

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Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans. Daneshjou R, Gamazon ER, Burkley B, et al. Blood 124(14), 2298-305, (2014)

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Knocking down 10-Formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement. Chang WN, Lee GH, Kao TT, et al. Biochim. Biophys. Acta 1840(7), 2340-50, (2014)

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The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach. Binder AM and Michels KB BMC Bioinformatics 14, 353, (2013)

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pH-sensitive polydopamine nanocapsules for cell imaging and drug delivery based on folate receptor targeting. Cheng FF, Zhang JJ, Xu F, et al. J. Biomed. Nanotechnol. 9(7), 1155-63, (2013)

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Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells. da Silva VR, Ralat MA, Quinlivan EP, et al. Am. J. Physiol. Endocrinol. Metab. 307(1), E93-101, (2014)

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Folate grafted Prussian Blue entrapped with gadolinium(III) as a new contrast agent for tumor-targeted magnetic resonant imaging. Song XX, Liu ZJ, and Tang Q J. Nanosci. Nanotechnol. 13(8), 5233-9, (2013)

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Suppressed mitochondrial biogenesis in folic acid-induced acute kidney injury and early fibrosis. Stallons LJ, Whitaker RM, and Schnellmann RG Toxicol. Lett. 224(3), 326-32, (2014)

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Folate and cobalamin modify associations between S-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults. Howe CG, Niedzwiecki MM, Hall MN, et al. J. Nutr. 144(5), 690-7, (2014)

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Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. Guariento AH, Furtado KS, de Conti A, et al. Int. J. Cancer 135(1), 7-18, (2014)

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Preparation and characterization of thermosensitive and folate functionalized Pluronic micelles. Yang C, Zhao H, Yuan H, et al. J. Nanosci. Nanotechnol. 13(10), 6553-9, (2013)

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Vitamins for the first 1000 days: preparing for life. Elmadfa I and Meyer AL Int. J. Vitam. Nutr. Res. 82(5), 342-7, (2012)

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Ionic complexation as a non-covalent approach for the design of folate anchored rifampicin Gantrez nanoparticles. Date PV, Patel MD, Majee SB, et al. J. Biomed. Nanotechnol. 9(5), 765-75, (2013)

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Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects? Obeid R, Holzgreve W, and Pietrzik K J. Perinat. Med. 41(5), 469-83, (2013)

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Maternal iron and folic acid supplementation is associated with lower risk of low birth weight in India. Balarajan Y, Subramanian SV, and Fawzi WW J. Nutr. 143(8), 1309-15, (2013)

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Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer's disease. Cacciapuoti F J. Thromb. Thrombolysis 36(3), 258-62, (2013)

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Determination of folate in infant formula and adult/pediatric nutritional formula by ultra-high performance liquid chromatography-tandem mass spectrometry: First Action 2013.13. Meisser-Redeuil K, Bénet S, Gimenez C, et al. J. AOAC Int. 97(4), 1121-6, (2014)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Pregnant immigrant Nigerian women: an exploration of dietary intakes. Lindsay KL, Gibney ER, McNulty BA, et al. Public Health 128(7), 647-53, (2014)

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Nutritional epidemiology of type 2 diabetes and depressive symptoms. Nanri A J. Epidemiol. 23(4), 243-50, (2013)

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Haematological implications of folate food fortification. Metz J S. Afr. Med. J. 103(12 Suppl 1), 978-81, (2013)

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Hyperhomocysteinemia is a risk factor for Alzheimer's disease in an Algerian population. Nazef K, Khelil M, Chelouti H, et al. Arch. Med. Res. 45(3), 247-50, (2014)

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Knowledge of periconceptional folic acid use among pregnant women at Ain Shams University Hospital, Cairo, Egypt. Al-Darzi W, Al-Mudares F, Farah A, et al. East. Mediterr. Health J. 20(9), 561-8, (2014)

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[History of the therapy of pernicious anemia]. Jeney A Orv. Hetil. 154(44), 1754-8, (2013)

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Intakes of dietary folate and other B vitamins are associated with risks of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. Sharp L, Carsin AE, Cantwell MM, et al. J. Nutr. 143(12), 1966-73, (2013)

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Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth. Gaskins AJ, Rich-Edwards JW, Hauser R, et al. Obstet. Gynecol. 124(1), 23-31, (2014)

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Molecular analysis of a UDP-GlcNAc:polypeptide alpha-N-acetylglucosaminyltransferase implicated in the initiation of mucin-type O-glycosylation in Trypanosoma cruzi. Heise N Glycobiology 19(8), 918-33, (2009)

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Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure. Yang C, Xie LY, Windle JJ, et al. FASEB J. 28(5), 1998-2008, (2014)

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Effects of folic acid on renal endothelial function in patients with diabetic nephropathy: results from a randomized trial. Schneider MP, Schneider A, Jumar A, et al. Clin. Sci. 127(7), 499-505, (2014)

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Impact of folate intake on prostate cancer recurrence following definitive therapy: data from CaPSURE™. Tomaszewski JJ, Richman EL, Sadetsky N, et al. J. Urol. 191(4), 971-6, (2014)

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Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expression. Zhao R, Diop-Bove N, and Goldman ID Mol. Pharmacol. 85(2), 310-21, (2014)

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Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women. Abbenhardt C, Miller JW, Song X, et al. J. Nutr. 144(5), 714-21, (2014)

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Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity. MacFarlane AJ, McEntee MF, and Stover PJ J. Nutr. 144(4), 419-24, (2014)

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The prevalence of low serum vitamin B-12 status in the absence of anemia or macrocytosis did not increase among older U.S. adults after mandatory folic acid fortification. Qi YP, Do AN, Hamner HC, et al. J. Nutr. 144(2), 170-6, (2014)

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Impact of folate therapy on combined immunodeficiency secondary to hereditary folate malabsorption. Kishimoto K, Kobayashi R, Sano H, et al. Clin. Immunol. 153(1), 17-22, (2014)

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European recommendations for primary prevention of congenital anomalies: a joined effort of EUROCAT and EUROPLAN projects to facilitate inclusion of this topic in the National Rare Disease Plans. Taruscio D, Arriola L, Baldi F, et al. Public Health Genomics 17(2), 115-23, (2014)

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Plasma folate concentrations and colorectal cancer risk: a case-control study nested within the Shanghai Men's Health Study. Takata Y, Shrubsole MJ, Li H, et al. Int. J. Cancer 135(9), 2191-8, (2014)

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Knowledge and periconceptional use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: systematic review and meta-analysis. Peake JN, Copp AJ, and Shawe J Birth Defects Res. A Clin. Mol. Teratol. 97(7), 444-51, (2013)

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Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana. Wei Z, Sun K, Sandoval FJ, et al. Arch. Biochem. Biophys. 536(1), 87-96, (2013)

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Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology. Joseph J and Loscalzo J Nutrients 5(8), 3235-56, (2013)

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Structural analysis of a fungal methionine synthase with substrates and inhibitors. Ubhi D, Kago G, Monzingo AF, et al. J. Mol. Biol. 426(8), 1839-47, (2014)

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Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. Shea B, Swinden MV, Tanjong Ghogomu E, et al. Cochrane Database Syst. Rev. 5, CD000951, (2013)

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Nutrition throughout life: folate. McNulty H, Pentieva K, Hoey L, et al. Int. J. Vitam. Nutr. Res. 82(5), 348-54, (2012)

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Intestinal absorption of raltitrexed and evaluation of the effects of absorption enhancers. Yu Y, Lu Y, Zhao X, et al. Pharmazie 68(9), 732-43, (2013)

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The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Herrington MB and Sitaras C Arch. Microbiol. 195(8), 559-69, (2013)

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Knowledge and practice of urban Iranian pregnant women towards folic acid intake for neural tube defect prevention. Nosrat SB, Sedehi M, and Golalipour MJ J. Pak. Med. Assoc. 62(8), 785-9, (2012)

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Anticancer activity of a hydrogel containing folic acid towards MCF-7 and MDA-MB-231 cells. Trombino S, Ferrarelli T, Pellegrino M, et al. Anticancer Res. 33(11), 4847-54, (2013)

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Synthesis and characterization of new derivatives of alginic acid and evaluation of their iron(III)-crosslinked beads as potential controlled release matrices. Abulateefeh SR, Khanfar MA, Al Bakain RZ, et al. Pharm. Dev. Technol. 19(7), 856-67, (2014)

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Micronutrients - a global perspective on intake, health benefits and economics. Hoeft B, Weber P, and Eggersdorfer M Int. J. Vitam. Nutr. Res. 82(5), 316-20, (2012)

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Seasonal folate serum concentrations at different nutrition. Krajcovicová-Kudlácková M, Valachovicová M, and Blazícek P Cent. Eur. J. Public Health 21(1), 36-8, (2013)

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A decreased micronucleus frequency in human lymphocytes after folate and vitamin B12 intervention: a preliminary study in a Yunnan population. Ni J, Liang Z, Zhou T, et al. Int. J. Vitam. Nutr. Res. 82(6), 374-82, (2012)

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The role of 401a>G polymorphism of methylenetetrahydrofolate dehydrogenase gene (MTHFD1) in fetal hypotrophy. Lorenc A, Seiemak-Mrozikiewicz A, Barlik M, et al. Ginekol. Pol. 85(7), 494-9, (2014)

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[The significance of folate metabolism in complications of pregnant women]. Seremak-Mrozikiewicz A Ginekol. Pol. 84(5), 377-84, (2013)

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An evaluation of nitric oxide, folate, homocysteine levels and lipid peroxidation in postmenopausal osteoporosis. Akpolat V, Bilgin HM, Celik MY, et al. Adv. Clin. Exp. Med. 22(3), 403-9, (2013)

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Warfarin pharmacogenetics: it matters if you're black or white. Wadelius M Blood 124(14), 2171, (2014)

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Valproate and folic acid in pregnancy: associations with autism. Baxter P Dev. Med. Child Neurol. 56(7), 604, (2014)

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BP targets in renal transplant recipients: too high or too low? Holdaas H and Jardine AG J. Am. Soc. Nephrol. 25(7), 1371-3, (2014)

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Folate augmentation of antidepressant response. Owen RT Drugs Today (Barc) 49(12), 791-8, (2013)

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Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk. Huang GL, Wang SK, Su M, et al. Biomed. Environ. Sci. 26(12), 1008-12, (2013)

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Why are we still measuring red cell folate instead of just serum folate? Pillay TS and Oosthuizen NM J. Clin. Pathol. 67(4), 289, (2014)

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Is folic acid a risk factor for oral clefts? Czeizel AE Eur. J. Epidemiol. 28(11), 841-3, (2013)

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Nutrients related to the incidence of early and late age-related macular degeneration. Kawada T Am. J. Clin. Nutr. 98(4), 1144, (2013)

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Maternal prenatal folic acid supplementation is associated with a reduction in development of autistic disorder. Berry RJ J. Pediatr. 163(1), 303-4, (2013)

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Should we be taking B vitamins to prevent age-related macular degeneration? Not yet, but worth doing more research. Evans J Am. J. Clin. Nutr. 98(1), 4-5, (2013)

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Maternal folic acid supplementation and risk of autism. Vahabzadeh A and McDougle CJ JAMA 309(21), 2208, (2013)

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Targeted molecular therapy for lung cancer: exuberance reestablished. Allen TC Arch. Pathol. Lab. Med. 137(6), 747, (2013)

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