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F8174 Sigma

Follicle Stimulating Hormone from sheep pituitary

Synonym: FSH

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Follicle Stimulating Hormone (FSH), Hormones,
storage temp.   2-8°C
Gene Information   human ... FSHR(2492)
sheep ... FSHB(443387)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Analysis Note

50 units per vial by the Steelman-Pohley assay using NIH-FSH-S1 reference standard.

Biochem/physiol Actions

The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.

FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS).

Other Notes

Two-chain glycoprotein hormone

Application

Follicle stimulating hormone from sheep pituitary has been used for-
• the in vitro maturation of bovine ovaries
• the hormonal treatment of Sertoli cells
• the intraperitoneal hormone treatment of male lizards
• the intramuscular hormone treatment of American alligator (Alligator mississippiensis)
• use in medium used for the maturation of bovine cumulus-oocyte complexes (COCs)

General description

FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where α subunit has resemblance to LH (luteinizing hormone), hCG (human chorionic gonadotropin) and TSH (thyrotropin-releasing hormone), which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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08168 Timestrip Plus 8 °C

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