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F8674 Sigma

Fas/Fc Chimera human

≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Synonym: Apo-1, CD95

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Death Receptors, Ligands and Antibodies, Death and Decoy Receptors,
recombinant   expressed in NSO cells
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
potency   0.01-0.04 μg per mL ED50 (in the presence of 2 ng/ml recombinant human Fas ligand for cytotoxicty assay of Jurkat cells)
mol wt   mol wt 45 kDa
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... FAS(355)

Description

Analysis Note

Biological activity was measured by its ability to inhibit Fas-ligand induced apoptosis of Jurkat cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin

Biochem/physiol Actions

Fas and its ligand play an essential role in apoptosis, by activating the cell death signaling pathway. Mutations in this gene are associated with evasion of apoptosis by cells, leading to tumorigenesis, and prevention of clearance of these cells by the immune system. A polymorphism in this gene results in the production of soluble Fas (sFas), which is implicated in the chronic autoimmune disorder called primary Sjögren′s syndrome (pSS).

Fas is a surface (trans-membrane) receptor that is a member of the TNF receptor/nerve growth factor receptor family. Fas receptor mediates apoptosis in a wide variety of cell types.

General description

Fas is a key component of apoptosis, and is a cell surface receptor. This gene is localized to human chromosome 10q24.1, and is composed of nine exons and eight introns.

Price and Availability


Flow Cytometry Instruments

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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