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F8675 Sigma

Fibroblast Growth Factor Receptor-4/Fc Chimera human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: FGFR-4/Fc Chimera

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Description

Analysis Note

The bioactivity is measured by its ability to inhibit human fibroblast growth factor acidic-dependent proliferation of NR6 cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Biochem/physiol Actions

FGFR4 (fibroblast growth factor receptor 4) is up-regulated in multiple tumors such as, pituitary, breast, pancreatic, hepatocellular, prostate and gynecological cancers. It functions as an oncogene in breast cancer, and is implicated in drug-resistance in colorectal cancer (CRC). Thus, it might have potential as a therapeutic target in CRC. Up-regulation of this gene in advanced gastric cancer (GC) results in accelerated progression, and it might have potential as a marker for prognosis of early-stage, well-differentiated GC.

General description

FGFR4 (fibroblast growth factor receptor 4) is a tyrosine kinase receptor, and belongs to the highly conserved FGFR family of four receptors. It contains three extracellular Ig (immunoglobulin) domains, which act as ligand-binding domains. FGF glycoproteins, which are 18 in number, act as ligand to this family of receptors. FGFR4 also contains a tyrosine kinase domain. It exists as a FGFR4-IIIc isoform.

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Safety & Documentation

Safety Information

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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