Fumitremorgin C
from Neosartorya fischeri, >98% (HPLC and TLC), film
DOWNLOAD MSDS (PDF)Synonym: FTC
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CAS Number 118974-02-0
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Empirical Formula (Hill Notation) C22H25N3O3
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Molecular Weight 379.45
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MDL number MFCD08702652
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PubChem Substance ID 24724486
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Popular Documents: Datasheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal, Bioactive Small Molecules, |
| biological source | from Neosartorya fischeri |
| assay | >98% (HPLC and TLC) |
| form | film |
| solubility | acetonitrile: soluble5 mg/mL |
| methanol: soluble5 mg/mL | |
| DMSO: soluble | |
| chloroform: soluble |
Description
Packaging
Store desiccated at 2-8 °C. Under these conditions, the product is stable for 2 years. A solution in DMSO is stable for 2 months at 2-8 °C.
Biochem/physiol Actions
Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glycoprotein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.
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