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F9505 Sigma

Furazolidone

Synonym: 3-(5-Nitrofurfurylideneamino)-2-oxazolidinone

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   PLHJDBGFXBMTGZ-WEVVVXLNSA-N
form   powder
mol wt   mol wt 225.16 g/mol
composition   Carbon, 41.8-43.6%
  Nitrogen (Dry Basis), 18.3-19.1%
mp   256-256 °C
solubility   formic acid: soluble50 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   Gram-positive bacteria
  parasites

Description

Packaging

10, 25, 100 g in glass bottle

Application

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes.

Biochem/physiol Actions

Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
RQ3675000
Protocols & Articles
Peer-Reviewed Papers
15

References

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