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F9507 Sigma

Flumethasone

Synonym: 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 6α,9α-Difluoro-16α-methylprednisolone, 6α-Fluorodexamethasone

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Biochemicals and Reagents
InChI Key   WXURHACBFYSXBI-GQKYHHCASA-N
form   solid
optical activity   [α]25/D 67.0 to 71.0°, c = 1 in dioxane
color   white
solubility   acetic acid: 10 mg/mL
Mode of action   cell membrane | interferes
storage temp.   2-8°C

Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.

Biochem/physiol Actions

Flumethasone is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding .

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TU3832000
Protocols & Articles

Articles

HPLC Analysis of Fluorinated Corticosteroids on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fluorinated Corticosteroids on Ascentis® C18
Keywords: Chromatography, Clinical, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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