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  • F9675 - Anti-FLIPL C-Terminal antibody produced in rabbit

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F9675 Sigma

Anti-FLIPL C-Terminal antibody produced in rabbit

~0.5 mg/mL, IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-CASHα

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Suppressors of Apoptosis,
species reactivity   mouse
application(s)   ELISA: suitable
  immunocytochemistry: suitable
  western blot: suitable
clone   polyclonal
concentration   ~0.5 mg/mL
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 53 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Cflar(12633)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 449-465 of the C-terminal region of mouse FLIPL.

General description

In human Viral FLICE-inhibitory proteins (v-FLIPs) is identified as c-FLIP. It is composed of two death effector domains which have structural resemblance with the N-terminal half of caspase-8 and a caspase-like domain. It exist as multiple splice variants: FLIP α, β, γ, δ. Along with splice variants, it has two endogenous forms of the protein c-FLIPlong and c-FLIPshort.

Physical form

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

Specificity

The antibody does not react with short form, FLIPS.

Application

Anti-FLIPL C-Terminal antibody is suitable for western blot at 1-2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.

Features and Benefits

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Biochem/physiol Actions

C-FLIP plays an important role in apoptosis signaling pathways. It acts as proapoptotic molecule or as an anti-apoptotic molecule. It has been reported that c-FLIP can interact with both FADD and caspase-8. It prevents caspase-8 recruitment and processing through DED-DED (death effector domain) interaction followed by CD95-induced apoptosis.

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