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F9911 Sigma

Fibronectin Proteolytic Fragment from human plasma

lyophilized powder, 30 kDa

Description

Application

Fibronectin protelytic fragments can be used for mapping regions, functions and activities of fibronectin. This fragment is adjacent to the N-terminal domain, containing the only gelatin binding site. It is an acidic isolectric point, does not bind to heparin, and is resistant to proteolysis because of intrachain disulfide bonding. These disulfide bonds are essential for binding to gelatin. The fragment will bind to C1q, but not to fibrin.

Caution

The product should be stored at -20°C.

Preparation Note

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

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