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  • F9925 - Anti-FLIPγ/δ, C-Terminal antibody produced in rabbit

F9925 Sigma

Anti-FLIPγ/δ, C-Terminal antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-CASH, Anti-CLARP, Anti-FLAME-1, Anti-I-FLICE


Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Suppressors of Apoptosis,
species reactivity   human, mouse
application(s)   microarray: suitable
  western blot: 1:500-1:1,000 using HeLa, Jurkat, THP-1, A431, K562, and NIH-3T3 cell lysates
clone   polyclonal
concentration   ~0.5 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 25 kDa (FLIPδ/FLIPS)
  antigen mol wt 35 kDa (FLIPγ)
Gene Information   human ... CFLAR(8837)
mouse ... Cflar(12633)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 191-209 of the C-terminal region of human FLIPγ/δ.

General description

In human Viral FLICE-inhibitory proteins (v-FLIPs) is identified as c-FLIP. It is composed of two death effector domains which have structural resemblance with the N-terminal half of caspase-8 and a caspase-like domain. It exist as multiple splice variants: FLIP α, β, γ and δ. Along with splice variants, it has two endogenous forms of the protein − c-FLIPlong and c-FLIPshort.

Physical form

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.


Anti-FLIPγ/δ, C-Terminal antibody is suitable for microarray and western blot at a dilution of 1:500-1:1,000 using HeLa, Jurkat, THP-1, A431, K562, and NIH-3T3 cell lysates.

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Biochem/physiol Actions

C-FLIP plays an important role in apoptosis signaling pathways. It acts as proapoptotic molecule or as an anti-apoptotic molecule. It has been reported that c-FLIP can interact with both FADD and caspase-8. It prevents caspase-8 recruitment and processing through DED-DED (Death Effector Domain) interaction followed by CD95-induced apoptosis.

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