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FD150S Sigma

Fluorescein isothiocyanate–dextran

average mol wt 150,000

Synonym: FITC–Dextran

Properties

Related Categories Alphabetical, Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates D-F,
mol wt   average mol wt 150,000
extent of labeling   0.003-0.025 mol FITC per mol glucose
solubility   H2O: soluble25 mg/mL, clear to slightly hazy, yellow-orange
storage temp.   2-8°C

Description

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.

FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. Small FITC-dextrans are also used to measure processes such as endocytosis and cell junction permeability. Fluorescein-dextran, 150 kDa may be used to help assess the integrity of the blood brain barrier (BBB) and to perform fluorescence microlymphography (FML). Fluorescein-dextran 150 is used as a microcirculation vascular flux tracer.

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