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FD70S Sigma

Fluorescein isothiocyanate–dextran

average mol wt 70,000

Synonym: FITC–Dextran

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Properties

Related Categories Alphabetical, Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates D-F,
mol wt   average mol wt 70,000
extent of labeling   0.003-0.020 mol FITC per mol glucose
solubility   H2O: soluble25 mg/mL, clear, yellow-orange
storage temp.   2-8°C

Description

Linkage

Similar to FD-70, but produced by Sigma.

Packaging

1, 5 g in poly bottle

100, 250 mg in poly bottle

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.

FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. Small FITC-dextrans are also used to measure processes such as endocytosis and cell junction permeability. FITC-dextran 70 kDa (FD-70) may be used as a model compound for development of methods to deliver molecules into protoplasts and to study drug release from structures such as hydrogels and liposomes. FD-70 may be used in microvascular and cell monolayer permeability studies.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Protocols

Fluorescein Isothiocyanate-Dextran

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.1,2,3  Conflicting data on the br...
Keywords: Bacterial conjugations, Chromatography, Fractionation

Peer-Reviewed Papers
15

References

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