Adenosine 5′-triphosphate (ATP) disodium salt hydrate

Papers

1. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Swennen EL Eur. J. Immunol. 35, 852-8, (2005)

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Allosteric inhibitors of Bcr-abl-dependent cell proliferation Adrian, F.J., et al. Nat. Chem. Biol. 2, 95-102, (2006)

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Design, synthesis, and antiviral activity of adenosine 5'-phosphonate analogues as chain terminators against hepatitis C virus. Yung-hyo Koh et al J. Med. Chem. 48, 2867-75, (2005)

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Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. Jie Ge et al J. Med. Chem. 49, 4606-15, (2006)

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Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. Alessio Ciulli et al J. Med. Chem. 49, 4992-5000, (2006)

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Nitric oxide activates TRP channels by cysteine S-nitrosylation. Takashi Yoshida et al Nat. Chem. Biol. 2, 596-607, (2006)

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Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. Andrei A Ivanov et al J. Med. Chem. 50, 1166-76, (2007)

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UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Schuichi Koizumi et al Nature 446, 1091-5, (2007)

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Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. Yongge Qiu et al Bioorg. Med. Chem. Lett. 17, 6164-8, (2007)

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Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase. Eisuke Murakami et al Antimicrob. Agents Chemother. 51, 503-9, (2007)

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Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor. James G Douglass et al J. Med. Chem. 51, 1007-25, (2008)

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Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity. Kei Moriyama et al J. Med. Chem. 51, 159-66, (2008)

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Specific small-molecule activator of Aurora kinase A induces autophosphorylation in a cell-free system. A Hari Kishore et al J. Med. Chem. 51, 792-7, (2008)

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Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. Williamson, D.S., et al. J. Med. Chem. 52, 1510-1513, (2009)

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Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling. Petra Hillmann et al J. Med. Chem. 52, 2762-75, (2009)

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Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. Leilei Zhang et al J. Med. Chem. 52, 4419-28, (2009)

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Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives. Liesbet Cosyn et al Bioorg. Med. Chem. Lett. 19, 3002-5, (2009)

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Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase. Nicolas Desroy et al Bioorg. Med. Chem. 17, 1276-89, (2009)

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Guide to Receptors and Channels (GRAC), 4th Edition. Br. J. Pharmacol. 158 Suppl 1, S1-254, (2009)

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Identification of hydrolytically stable and selective P2Y(1) receptor agonists. Shay E Eliahu et al Eur. J. Med. Chem. 44, 1525-36, (2009)

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A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold. Shay Eliahu et al J. Med. Chem. 53, 2472-81, (2010)

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2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure. Shay Eliahu et al J. Med. Chem. 53, 3305-19, (2010)

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ATPases as drug targets: insights from heat shock proteins 70 and 90. Andrew J Massey et al J. Med. Chem. 53, 7280-6, (2010)

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Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses. Runzhi Wu et al J. Med. Chem. 53, 7958-66, (2010)

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Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors. Shay Eliahu et al J. Med. Chem. 53, 8485-97, (2010)

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2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. Maria A Argiriadi et al Bioorg. Med. Chem. Lett. 20, 330-3, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Mutant APH(2'')-IIa enzymes with increased activity against amikacin and isepamicin. Marta Toth et al Antimicrob. Agents Chemother. 54, 1590-5, (2010)

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A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition. Yanhui Yang et al Bioorg. Med. Chem. Lett. 21, 3943-6, (2011)

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Role of adenosine 5′-triphosphate in regulating renal microvascular function and in hypertension. Guan Z, Inscho EW. Hypertension 58, 333-340, (2011)

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