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G0278 Sigma

Galanin human

≥97% (HPLC), powder

  • CAS Number 119418-04-1

  • Empirical Formula (Hill Notation) C139H210N42O43

  • Molecular Weight 3157.41

  •  MDL number MFCD00135986

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Galanins, Neuropeptides, Peptides and Proteins,
InChI Key   CBSXZYWGVAQSHI-RUKUCZSXSA-N
assay   ≥97% (HPLC)
form   powder
composition   Peptide content, ≥70%
storage temp.   −20°C
Gene Information   human ... GAL(51083)

Description

Amino Acid Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser

Other Notes

Lyophilized from 0.1% TFA in H2O

Application

Galanin human has been used in immunohistochemistry performed on ileums of pigs to study the effect of the mycotoxin zearalenone on the expression of intestinal peptides.

Biochem/physiol Actions

Galanin (GAL) is involved in multiple physiological actions such as, nociception, cognition, memory, hunger, hormone and neurotransmitter release, and cell growth. It also controls the release of gastric acid, plays a role in the contraction of intestines, and suppresses the secretion of pancreatic peptides. This peptide is up-regulated in colorectal cancer (CRC), which relates to aggressive phenotype and poor prognosis of patients with stage II CRC. Studies in Chinese Han female population show that polymorphisms in this gene are linked to susceptibility to depression.

General description

Galanin (GAL) is a neuropeptide composed of 29 amino acids. It has wide range of expression in central and peripheral nervous system. It acts as a ligand for three G-protein coupled receptor (GPCR) subtypes called GalR1, GalR2 and GalR3.

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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