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G0290 Sigma

Anti-GATA1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-ERYF1, Anti-Erythroid transcription factor 1, Anti-Globin transcription factor 1

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins, Bioactives, Markers, and Receptors for Stem Cell Biology, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Cell Biology,
species reactivity   human
application(s)   microarray: suitable
  western blot: 1:200 using a whole extract from a human chronic myelogenous leukemia cell line, K562
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 45 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... GATA1(2623)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the C-terminal region of human GATA-1 (amino acids 394-413).

General description

GATA is an important cis-element factor in the haematopoietic lineage belongs to GATA-binding protein family. It was first identified in the analysis of globin gene promoters and enhancers. There are different types of GATA proteins: GATA-1, GATA-2, GATA-3. It is expressed in erythroid, mast, megakaryocytic lineages, multipotential progenitor cells and lines.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Application

Anti-GATA1 antibody is suitable for immunoblot analysis of conceptuses cells to study the expression of GATA1 in ovine conceptuses during the peri-attachment period. It is also suitable for microarray and western blot at a dilution of 1:200 using a whole extract from a human chronic myelogenous leukemia cell line, K562.

Features and Benefits

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Biochem/physiol Actions

GATA is a lineage-restricted transcription factor which plays a pivotal role in erythroid differentiation. It possesses potential binding sites in the regulatory sequences of all erythroid genes. GATA is expressed at higher levels during erythroid maturation. It is essential for terminal differentiation of erythrocytes and megakaryocytes and associated in vivo with the acetyl transferase p300/CBP. Mutation in GATA1 causes thrombocytopenia and abnormal platelet function.

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