|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G,|
|solubility||ethanol: soluble2 mg/mL|
human ... KCNH2(3757), KCNJ1(3758), KCNJ11(3767)|
rat ... Kcnj1(24521)
5, 10 g in poly bottle
Selectively blocks ATP-sensitive K+ channels; high affinity binding sites found in brain, pancreatic β cells, and cardiovascular system.
Certificate of Analysis
Certificate of Origin
Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
Keywords: Absorption, Cancer, Cell proliferation, Cell signaling, Diabetes, Diseases, Hormones, Ligands, Neurotransmitters, Phosphorylations, Sequencing
Glibenclamide induces apoptosis through inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and intracellular Ca(2+) release in HepG2 human hepatoblastoma cells. Kim, J.A., et al. Biochem. Biophys. Res. Commun. 261, 682, (1999)
Saxagliptin efficacy and safety in patients with type 2 diabetes mellitus and cardiovascular disease history or cardiovascular risk factors: results of a pooled analysis of phase 3 clinical trials. Cook W, Bryzinski B, Slater J, et al. Postgrad. Med. 125(3), 145-54, (2013)
Interactions between A(2A) adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia. Sharifi-Sanjani M, Zhou X, Asano S, et al. Am. J. Physiol. Heart Circ. Physiol. 304(10), H1294-301, (2013)
Comparison of effects of ATP-gated potassium channel blockers on activity variations of rat CA1 pyramidal neurons in hippocampal slices triggered by short-term hypoxia. Levin SG, Shamsutdinova AA, and Godukhin OV Bull. Exp. Biol. Med. 154(4), 441-4, (2013)
Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. Gama KB, Quintans JS, Antoniolli AR, et al. J. Nat. Prod. 76(4), 559-63, (2013)
Selective separation and enrichment of glibenclamide in health foods using surface molecularly imprinted polymers prepared via dendritic grafting of magnetic nanoparticles. Wang R, Wang Y, Xue C, et al. J. Sep. Sci. 36(6), 1015-21, (2013)
Reduced capacity of heart rate regulation in response to mild hypoglycemia induced by glibenclamide and physical exercise in type 2 diabetes. Soydan N, Bretzel RG, Fischer B, et al. Metabolism 62(5), 717-24, (2013)
The R230C variant of the ATP binding cassette protein A1 (ABCA1) gene is associated with a decreased response to glyburide therapy in patients with type 2 diabetes mellitus. Aguilar-Salinas CA, Muñoz-Hernandez LL, Cobos-Bonilla M, et al. Metabolism 62(5), 638-41, (2013)
Attenuation of islet-specific T cell responses is associated with C-peptide improvement in autoimmune type 2 diabetes patients. Brooks-Worrell BM and Palmer JP Clin. Exp. Immunol. 171(2), 164-70, (2013)
Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. Mathias R and von der Weid PY Am. J. Physiol. Gastrointest. Liver Physiol. 304(6), G623-34, (2013)
Comparison of the effects of glibenclamide on metabolic parameters, GLUT1 expression, and liver injury in rats with severe and mild streptozotocin-induced diabetes mellitus. Sokolovska J, Isajevs S, Sugoka O, et al. Medicina (Kaunas.) 48(10), 532-43, (2012)
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