|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G,|
|solubility||ethanol: soluble2 mg/mL|
human ... KCNH2(3757), KCNJ1(3758), KCNJ11(3767)|
rat ... Kcnj1(24521)
Selectively blocks ATP-sensitive K+ channels; high affinity binding sites found in brain, pancreatic β cells, and cardiovascular system.
Certificate of Analysis
Certificate of Origin
Glibenclamide induces apoptosis through inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and intracellular Ca(2+) release in HepG2 human hepatoblastoma cells. Kim, J.A., et al. Biochem. Biophys. Res. Commun. 261, 682, (1999)
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