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G0666 Sigma

Anti-Glycine Receptor antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to GABA and Glycine Receptors,
species reactivity   human, rat
application(s)   immunoprecipitation: suitable
  western blot: suitable using rat spinal cord and cell extracts containing the recombinant human glycine receptors
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   2-8°C
Gene Information   human ... GLRA1(2741), GLRA2(2742)
rat ... Ptk2(25674)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide from the amino terminus of the human α1 glycine receptor subunit.

Physical form

Lyophilized powder from 5 mM ammonium bicarbonate.

Specificity

The antibody recognizes the α1 glycine receptor and cross-reacts with human α2 glycine receptor subunits.

Application

Anti-Glycine Receptor antibody is suitable for western blot analysis of immunoprecipitates of rat spinal cord (lane 2) and human sperm extract in the detection of GlyR in human sperm.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

Glycine receptors act as excitatory neurotransmitter as well as inhibitory receptor. It plays a central role in acrosome reaction (AR). Mutations in the GLRA1 gene encoding the α1-subunit of the glycine receptor causes startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.

Price and Availability


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