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G0769 Sigma

Growth Hormone Releasing Factor porcine

≥97% (HPLC), powder, synthetic

Synonym: GRF

  • CAS Number 88384-73-0

  • Empirical Formula (Hill Notation) C219H365N73O66S

  • Molecular Weight 5108.76

  •  MDL number MFCD00081667

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, GH-RH, Growth Hormone Releasing Factors, Neuropeptides,
biological source   synthetic
assay   ≥97% (HPLC)
form   powder
storage temp.   −20°C
Gene Information   human ... GHRHR(397100)

Description

Amino Acid Sequence

Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu-Gln-Gly-Ala-Arg-Val-Arg-Leu-NH2

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of somatotropin from anterior pituitary

Growth hormone releasing factor (GHRF) binds to GHRF receptors in the anterior pituitary, leading to the production and release of GH (growth hormone). GH induces the production of the mitogen insulin-like growth factor-I in the liver. In peripheral organs and cancer, GHRF has a paracrine/autocrine function. It is abnormally expressed in gynecological tumors, pancreatic, lung and prostate cancer. This protein might be responsible for pathogenesis of endometrioid type of endometrial cancers. It is essential for the amplification of GH secretion during night time.

Application

Growth hormone releasing factor (GHRF) procine has been used for GHRH challenge test in pigs, 48hrs post- intravenous glucose tolerance test (IVGTT).

General description

Growth hormone releasing factor (GHRF) is a hypothalamus-secreted peptide composed of 40-44 amino acids. This protein is expressed by organs such as, ovaries, testis and placenta, and cells such as, lymphocytes.

Price and Availability


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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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