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G1001 Sigma

D-Glutamic acid

≥99% (TLC)

Synonym: (R)-2-Aminoglutaric acid, (R)-2-Aminopentanedioic acid, D-Glu, R-(−)-1-Aminopropane-1,3-dicarboxylic acid

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Properties

Related Categories Asymmetric Synthesis, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Chiral Resolution Reagents,
InChI Key   WHUUTDBJXJRKMK-GSVOUGTGSA-N
assay   ≥99% (TLC)
mp   200-202 °C (subl.)(lit.)
Gene Information   human ... CCR2(1231)

Description

Biochem/physiol Actions

Unnatural isomer of glutamic acid.

Packaging

1, 5, 25, 100 g in poly bottle

Application

D-glutamic acid is suitable for use in the structure-affinity relationship (SAR)-study of GR (glutamate racemase) enzyme and its inhibitors.

General description

D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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