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G1036 Sigma

Gossypin

≥90% (TLC), from Hibiscus vitifolius

Synonym: 2-(3,4-Dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy- 4H-1-benzopyran-4-one, 3,3′,4′,5,7,8-Hexahydroxyflavone 8-glucoside, Gossypetin 8-glucoside

  • CAS Number 652-78-8

  • Empirical Formula (Hill Notation) C21H20O13

  • Molecular Weight 480.38

  •  MDL number MFCD00017429

Properties

biological source   from Hibiscus vitifolius
assay   ≥90% (TLC)

Description

Biochem/physiol Actions

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

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