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G114 Sigma

GR 73632

>97%

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Properties

Related Categories Agonist, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators,
InChI Key   HQKPTSSZOJLFBZ-LJADHVKFSA-N
assay   >97%
storage temp.   −20°C
Gene Information   human ... TAC1(6863), TACR1(6869)
mouse ... TAC1(21333), TACR1(21336)
rat ... TAC1(24806), TACR1(24807)

Description

Amino Acid Sequence

H2N-(CH2)4-CO-Phe-Pro-NMe-Leu-Met-NH2

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

GR 73632 interacts with neurokinin (NK1) receptor, which results in rhythmic tapping of hind-foot in gerbils. Administration of this peptide in the intra-ventral tegmental area (VTA) results in locomotor activity. It interacts with and activates NK1 receptors present on smooth muscle and interstitial cells of Cajal, resulting in elevated distention-induced peristalsis.

General description

Neurokinin (NK) receptors are acted upon by tachykinins or neurokinins namely, NKA and NKB. These are endogenous ligands. An exogenous agonist/ligand for NK1 is GR 64349 petpide.

Price and Availability


Making Headway

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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