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G119 Sigma

GYKI 52466 hydrochloride


Synonym: 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride

  • CAS Number 192065-56-8

  • Empirical Formula (Hill Notation) C17H15N3O2 · HCl

  • Molecular Weight 329.78

  •  MDL number MFCD00153803

  •  PubChem Substance ID 24277984



Related Categories AMPA/Kainate Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   solid
color   yellow
solubility   DMSO: soluble0.39 mg/mL
  ethanol: soluble0.4 mg/mL
  0.1 M HCl: soluble0.68 mg/mL
  methanol: soluble1 mg/mL
  H2O: >10 mg/mL
Gene Information   human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)


Biochem/physiol Actions

Selective allosteric AMPA receptor antagonist; anti­convulsant; skeletal muscle relaxant.

Legal Information

Sold under exclusive license from the Institute for Drug Research Ltd., Budapest, Hungary.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Price and Availability

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Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Peer-Reviewed Papers


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