L-Glutamic acid

Papers

Amino-acid Imbalance Explains Extension Of Lifespan By Dietary Restriction In Drosophila. Grandison, R.C., et al. Nature 462, 1061-4, (2009)

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Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes. Vladimir N Noskov et al Biol. Proced. Online 13, 8, (2011)

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2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. Patrizia Minetti et al J. Med. Chem. 48, 6887-96, (2005)

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Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3. Sebastien Alaux et al J. Med. Chem. 48, 7980-92, (2005)

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Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships. Sergio A Alonso De Diego et al Bioorg. Med. Chem. Lett. 15, 2279-83, (2005)

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(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors. William J Wheeler et al Bioorg. Med. Chem. Lett. 15, 349-51, (2005)

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Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3. Sophie Faure et al J. Med. Chem. 49, 6532-8, (2006)

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Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. Laura Amori et al Bioorg. Med. Chem. Lett. 16, 196-9, (2006)

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Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. Cyril Barinka et al J. Med. Chem. 50, 3267-73, (2007)

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Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA. Anders A Jensen et al J. Med. Chem. 50, 4177-85, (2007)

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Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. Roberto Pellicciari et al J. Med. Chem. 50, 4630-41, (2007)

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Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Olga Boudker et al Nature 445, 387-93, (2007)

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Exploitation of structural and regulatory diversity in glutamate racemases. Tomas Lundqvist et al Nature 447, 817-22, (2007)

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Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. Maura Marinozzi et al Bioorg. Med. Chem. 15, 3161-70, (2007)

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Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid. Andrea Pinto et al J. Med. Chem. 51, 2311-5, (2008)

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Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2. Emanuelle Sagot et al J. Med. Chem. 51, 4085-92, (2008)

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Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. Emanuelle Sagot et al J. Med. Chem. 51, 4093-103, (2008)

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N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. Rasmus P Clausen et al J. Med. Chem. 51, 4179-87, (2008)

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1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators. Stefania Butini et al J. Med. Chem. 51, 6614-8, (2008)

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The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization. Rasmus P Clausen et al J. Med. Chem. 52, 4911-22, (2009)

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Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands. Rosanna Filosa et al Bioorg. Med. Chem. 17, 242-50, (2009)

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Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Griet Van Zeebroeck et al Nat. Chem. Biol. 5, 45-52, (2009)

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4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. Marco L Lolli et al J. Med. Chem. 53, 4110-8, (2010)

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Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands Fleming J.J. , et al. Bioorg. Med. Chem. 18, 1381-1387, (2010)

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Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Shigeo Hayashi et al Bioorg. Med. Chem. 18, 7675-99, (2010)

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Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. Raminta Venskutonyte et al J. Med. Chem. 54, 4793-805, (2011)

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Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors. Re?it Çakmak et al Bioorg. Med. Chem. Lett. 21, 5398-402, (2011)

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The metabotropic glutamate receptors: structure and functions. Pin, J-P. Neuropharmacology 34, 1, (1995)

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Merck 14,4469

Beil. 4,IV,3028

Aldrich MSDS 1, 991:B / Arctander, 1466 / Corp MSDS 1 (1), 1776:A / FT-IR 2 (1), 935:C / FT-IR 1 (1), 590:A / Fenaroli, 301 / IR-Spectra (3), 351:D / IR-Spectra (2), 312:C / NMR-Reference 2 (1), 497:B / RegBook 66 (1), 671:A / RegBook 1 (1), 671:A / Sax 6, 1478 / Sigma FT-IR 1 (1), 170:B / Structure Index 1, 100:B:8