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G1253 Sigma

Xanthan gum from Xanthomonas campestris

Synonym: Gum xanthan

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Description

Other Notes

A polysaccharide containing glucose, mannose, potassium glucuronate, acetate and pyruvate. Forms a hydrophilic colloid.

Packaging

100, 500 g in poly bottle

Application

Xanthan gum is an anionic polysaccharide composed of a β-(1→4)-D-glucopyranose glucan backbone with side chains of (1→3)-α-D-mannopyranose-(2→1)-β-D-glucuronic acid-(4→1)-β-D-mannopyranose on alternating residues. Approximately half of the terminal mannose residues are 4,6-pyruvated while most of the inner mannose residues are 6-acetylated. Its properties make it a useful matrix component for drug delivery systems. It forms stable drug suspensions in aqueous media and soft gels with locust bean gum or guar gum. Xanthan gum mimics the texture of lipids and is used as a control in experiments where signaling pathways initiated by consumption of lipid-containing reagents are investigated in mice. 1

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Safety & Documentation

Safety Information

WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. Gaillard, D. FASEB J. 22, 1458-1468, (2008)

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Formulation development and stability studies of aqueous metronidazole benzoate suspensions containing various suspending agents. Zietsman, S., et al. Drug Devel. Ind. Pharm. 33, 191-197, (2007)

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Characterization of polysaccharide hydrogels for modified drug delivery. Sandolo. C., et al. Eur. Biophys. J., Apr 11 e-pub, (2007)

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Evaluation and controlled release characteristics of modified xanthan films for transdermal delivery of atenolol. Mundarqi, R.C., et al. Drug Devel. Ind. Pharm. 33, 79-90, (2007)

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Gelation of native β-lactoglobulin induced by electrostatic attractive interaction with xanthan gum. Laneuville, S.I., et al. Langmuir 22, 7351-7357, (2006)

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Biodegradation of Xanthan Gum by Bacillus sp. Cadmus, M.C., et al. Appl. Environ. Microbiol. 44, 5-11, (1982)

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The influence of the primary and secondary xanthan structure on the enzymatic hydrolysis of the xanthan backbone. Kool MM, Schols HA, Delahaije RJ, et al. Carbohydr. Polym. 97(2), 368-75, (2013)

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Rheological characteristics of cold thickened beverages containing xanthan gum-based food thickeners used for dysphagia diets. Cho HM and Yoo B J. Acad. Nutr. Diet. 115(1), 106-11, (2015)

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Xanthan gum biosynthesis and application: a biochemical/genetic perspective. Becker A, Katzen F, Pühler A, et al. Appl. Microbiol. Biotechnol. 50(2), 145-52, (1998)

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Investigations into the tensile failure of doubly-convex cylindrical tablets under diametral loading using finite element methodology. Podczeck F, Drake KR, and Newton JM Int. J. Pharm. 454(1), 412-24, (2013)

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Effects of bolus rheology on aspiration in patients with Dysphagia. Leonard RJ, White C, McKenzie S, et al. J. Acad. Nutr. Diet. 114(4), 590-4, (2014)

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Xanthan gum and its derivatives as a potential bio-polymeric carrier for drug delivery system. Badwaik HR, Giri TK, Nakhate KT, et al. Curr. Drug Deliv. 10(5), 587-600, (2013)

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Physico-chemical stability of astaxanthin nanodispersions prepared with polysaccharides as stabilizing agents. Anarjan N and Tan CP Int. J. Food Sci. Nutr. 64(6), 744-8, (2013)

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Formulation and in vitro assessment of sustained release terbutaline sulfate tablet made from binary hydrophilic polymer mixtures. Al-Akayleh F, Al Remawi M, Rashid I, et al. Pharm. Dev. Technol. 18(5), 1204-12, (2013)

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Merck 14,10057

FT-IR 2 (1), 294:C / RegBook 1 (1), 201:I / Sigma FT-IR 1 (1), 1490:B

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