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G1269 Sigma

Gly-Arg-Gly-Asp-Ser-Pro-Lys

≥97% (HPLC)

Synonym: GRGDSPK

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Description

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro-Lys

Biochem/physiol Actions

Fibronectin analog that binds to integrins.

Application

Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-
• as a blocking peptide to inhibit integrin-fibronectin binding
• in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
• for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
• for the preparation of RGD.Flt23k.NR nanoparticles
• to determine the involvement of RGD-integrin bonding in cell adhesion process

General description

Gly-Arg-Gly-Asp-Ser-Pro-Lys is a synthetic Arg-Gly-Asp (RGD) peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.

Price and Availability


Detect Your Unseen Protein

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Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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