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  • G1298 - Anti-GAB1 (222-235) antibody produced in rabbit

G1298 Sigma

Anti-GAB1 (222-235) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-GRB2-associated binding protein 1



Related Categories Alphabetical Index, Antibodies, G-GC, Primary Antibodies
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~77 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... GAB1(2549)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 222-235 of human GAB1

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Anti-GAB1 (222-235) antibody is suitable for western blot at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

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Biochem/physiol Actions

GAB1 is adaptor molecule with molecular mass of 115kD. It plays a key role in the intracellular signaling of the hepatocyte growth factor (HGF) receptor. Upon activation GAB1 has shown to associate with molecular adapter GRB2, phospholipase Cγ (PLCγ), phosphotyrosine phosphatase SHP2, and PI 3-kinase. It also acts as a substrate for receptor tyrosine kinase c-Met in the c-Met-specific cell dissociation and branching morphogenesis. Over-expression of Gab1 enhances cell growth by accelerating the cell transformation activities.

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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