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G151 Sigma

Anti-GROα antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   IgG fraction of antiserum
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... CXCL1(2919)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human GROα/MGSA expressed in Escherichia coli.

General description

Chemokines are cytokines that induce migration of leukocytes in response to inflammatory stimuli. The members of the CXC family of chemikones are GRO and Interleukin-8. Within this family, GRO-α is reported to have a specific ELR: glutamate, leucine, arginine motif that is important to attract the neutrophils and stimulate angiogenesis. Multiple functions have been identified for GRO-α. Due to its ability to recruit neutrophils, GRO-α has been found important in the pathology of inflammatory diseases such as atherosclerosis. Smooth muscle cells of the airway produce GRO-α to attract neutrophils in chronic obstructive pulmonary disease that contributes to obstruction of airway. The ability of GRO-α to induce angiogenesis shows that it is involved in the angiogenesis, the associated metastasis and tumorigenesis of pancreatic and gastric cancers
Anti-GRO-α antibody specifically recognizes human GRO-α. It shows 60% cross-reactivity with human GRO-β and less than 30% cross-reactivity with human GRO-γ.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Specificity

The antibody shows approximately 30% cross-reactivity with recombinant human GROβ, recombinant human GROγ, and recombinant mouse MIP-2. It also approximately shows 20% cross-reactivity with recombinant rat CINC-1 and approximately 10% cross-reactivity with recombinant rat CINC-2α, recombinant rat CINC-2β, recombinant mouse KC, recombinant human IL-8, and recombinant human NAP-2.

Preparation Note

Purified using protein G.

Application

Anti-GRO-α antibody is suitable for indirect ELISA and immunoblotting.

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