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G1542 Sigma

Glucocorticoid Receptor human

recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution

Synonym: GR

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Gene Regulation and Expression,
recombinant   expressed in baculovirus infected insect cells
form   buffered aqueous solution
mol wt   mol wt 85.6 kDa
packaging   vial of 25 (pmol)
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... NR3C1(2908)

Description

Physical form

Solution of 10 mM potassium phosphate buffer, pH 7.4, 5 mM DTT, 0.1 mM EDTA, 10 mM sodium molybdate, and 10% glycerol.

Application

Glucocorticoid Receptor human (hGR) has been used to study its influence on monocyte chemoattractant protein 1 (MCP-1) accumulatio in dexamethasone treated cells, and for the determination of interactions between MCP-1 mRNA and GR.

Biochem/physiol Actions

Glucocorticoid Receptor (GR) acts upon and mediates the actions of glucocorticoids which are essential for normal physiological processes. In mothers with postnatal depression, this gene is methylated at the promoter in infants. This effect is suppressed by stroking of infants by their mothers. Various infectious disease-related genes in the GR signal transduction pathway are influenced by prenatal exposure to arsenic and cadmium.

General description

Glucocorticoid Receptor (GR) is an intracellular, ligand-dependent transcription factor, which shows a ubiquitous expression pattern. It is a member of the steroid/thyroid/retinoic acid nuclear receptor superfamily of transcription factors and is localized to human chromosome 5. The encoded receptor is composed of an NH2-terminal domain, a DNA-binding domain (DBD), hinge region and the ligand-binding domain (LBD). Alternative splicing gives rise to five isoforms namely hGRα, hGRβ, hGRγ, hGR-A and hGR-P.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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