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G1667 Sigma

GITR/Fc Chimera human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: AITR, Activation-inducible TNFR, Glucocorticoid-induced TNF Receptor

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, TNF Receptors,
recombinant   expressed in NSO cells
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   calculated mol wt 41 kDa
  mol wt ~50 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   human ... TNFRSF18(8784)

Description

Analysis Note

The biological activity is measured by its ability to bind GITR ligand.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Biochem/physiol Actions

Studies in mice show that glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) can induce autoimmune thyroiditis, experimental allergic encephalomyelitis, autoimmune myocarditis, hapten-induced colitis or inflammatory bowel disease, which are all autoimmune disorders. In multiple myeloma (MM), this protein functions as a tumor suppressor, and an elevation in its expression results in enhanced sensitivity to Bortezomib. Abnormal expressions of this protein in MM is linked with tumor progression, poor prognosis and survival.

Type I transmembrane protein in the TNFR family. Appears to act in conjunction with the GITR ligand, to protect T cells against activation-induced cell death.

General description

Glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) is a member of the tumour necrosis factor receptor (TNFR) superfamily, and hence, is commonly known as TNFRSF18. It is a type I membrane protein. This protein shows high constitutive expression levels on regulatory T cells. However, on resting effector CD4+ T cells, this receptor shows very low levels of expression, which are sharply increased post-activation.

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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