• USA Home
  • G3381 - Geldanamycin from Streptomyces hygroscopicus

EMAIL THIS PAGE TO A FRIEND
G3381 Sigma

Geldanamycin from Streptomyces hygroscopicus

≥98% (HPLC), powder

Purchase

Description

Packaging

1 mg in glass bottle

Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Price and Availability


Better Together

Discover your Target

Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
LX8920000
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

HPLC Analysis of Geldanamycin and 17-(Allylamino)-17-demethoxy geldanamycin on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Geldanamycin and 17-(Allylamino)-17-demethoxy geldanamycin on Ascentis® Express C18
Keywords: Antibiotics, Chromatography, Clinical, High performance liquid chromatography, Separation, Solvents

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?