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G4877 Sigma

Gonadotropin from pregnant mare serum

≥1,000 IU/mg

Synonym: Equine gonadotropin, PMSG, Pregnant mare serum gonadotropin, eCG

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Description

Application

Gonadotropin from pregnant mare serum has been used-
• for inducing superovulation in female Sprague Dawley rats
• for injection in female golden hamster to eventually obtain zona-free hamster eggs

Biochem/physiol Actions

Gonadotropin interacts with members of the GPCR (G-protein coupled receptor family), and upon activation they induce adenylyl cyclase.

Two chain glycoprotein hormone; stimulates the growth of ovarian follicles and the formation of the corpus luteum.

General description

Gonadotropin hormone is only found in primates and is a member of the glycoprotein hormone family, which also consists of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). This hormone is composed of two non-covalently linked α and β subunits. The α-subunits within a species are identical, whereas the β subunits are different, which confers the differences in physiological specificity.

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
TU4517000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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CG10 Chorionic gonadotropin human, lyophilized powder, vial of ~10,000 IU
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