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G5009 Sigma

γ-Globulins from bovine blood

≥99% (agarose gel electrophoresis)

Synonym: Bovine γ-Globulin

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Properties

Related Categories Application Index, Biochemicals and Reagents, Enzymes, Inhibitors, and Substrates, Globulins, Plasma & Blood Proteins,
Quality Level   PREMIUM
assay   ≥99% (agarose gel electrophoresis)
composition   NaCl, ≤4%
solubility   0.9% NaCl: soluble 25 mg/mL
storage temp.   −20°C

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

Bovine γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.

Bovine γ-globulins were used to study the constituents and pH changes in protein rich hyaluronan solution which affect the biological properties of artificial articular joints. It is also used to determine immunoglobulin G in bovine colostrum and milk using direct biosensor SPR-immunoassay.

General description

Plasma protein fraction rich in antibodies

Packaging

1, 5, 10, 25, 100 g in poly bottle

Preparation Note

Prepared from Cohn Fraction II, III

Biochem/physiol Actions

The γ-G globulins of bovine serum are categorized by anion exchange chromatography, immunoelectrophoresis, zone electrophoresis, ultracentrifugation, and analysis of the products of papain digestion. They have properties similar to analogous components of human serum. This was determined by the methods such as: gel filtration, immunoelectrophoresis, anion exchange chromatography, ultracentrifugation, and reduction with mercaptoethanol. Fast and slow γ-G globulins were classified on the basis of differences in electrophoretic migration rates, chromatographic elution positions, and biological activities (complement fixation). Bovine γ-A was conditionally found in immunoelectrophoretic analyses of serum and chromatographic fractions.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
What is the molecular weight of Product G5009, γ-Globulins from bovine blood?
The molecular weight of 150,000 is based on 2 heavy chains (55,000 each) and 2 light chains (20,000 each).
What is the class of immunoglobulins in Product G5009, γ-Globulins from bovine blood?
The gamma-globulin is a mixture of IgG (80%), IgM (10%), and IgA (<10%).
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

HPLC Analysis of Proteins on Zenix® SEC-300, 30 cm x 4.6 mm I.D., 3 μm

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proteins on Zenix® SEC-300, 30 cm x 4.6 mm I.D., 3 μm
Keywords: Chromatography, High performance liquid chromatography, Separation, Size-exclusion chromatography

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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