|Related Categories||Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines as adjuvants,|
|recombinant||expressed in E. coli|
|assay||≥98% (SDS-PAGE and HPLC)|
|potency||≤0.1 ng/mL EC50|
|mol wt||mol wt 14.6 kDa|
|suitability||suitable for cell culture|
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The proliferative activity of human GM-CSF is tested in culture using human TF-1 cells.1
Granulocyte-macrophage colony stimulating factor is a growth and differentiation factor for cells in the granulocyte, macrophage and eosinophil lineage. GM-CSF stimulates colony formation from pluripotential progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. It also stimulates growth in some epithelial cells and osteoclasts. GM-CSF is produced by a variety of cell types (monocytes, endothelial cells, T-cells, fibroblasts, mitogen-stimulated B-cells, and LPS-stimulated macrophages). GM-CSF is secreted as a single chain glycoprotein containing 128 amino acids for human with a conserved disulfide bond. Human and murine GM-CSF share approx. 54% sequence homology and do not cross-react in bioactivity.
Package size based on protein content
Lyophilized from a 0.2 μm filtered, 10 mM sodium citrate, pH 3.5 solution.
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Certificate of Analysis
Certificate of Origin
Nicola, N.A., Nicola, N.A., ed. Guidebook to Cytokines and Their Receptors NY, NY , (1994), 171
Quesniaux, V.F.J., Jones, T.C. The Cytokine Handbook 3rd ed., San Diego, CA , (1998), 637
Callard, R., Gearing, A. The Cytokine Facts Book New York, NY , (1994)
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