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G5165 Sigma

Anti-Gαx/z antibody produced in rabbit

whole antiserum

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to G Proteins, Antibodies to G Proteins and Cyclic Nucleotides,
species reactivity   mammals
application(s)   western blot: 1:100-1:200 using plasma membrane fractions
clone   polyclonal
antibody form   whole antiserum
contains   0.1% sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... GNAZ(2781)
mouse ... Gnaz(14687)
rat ... Gnaz(25740)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the C-terminal region of Gαx/z.

General description

G-proteins are membrane associated heterotrimeric proteins that are comprised of α-, β-, and γ-subunits. These proteins play a key role in signal transduction pathways that regulate cell′s response to several hormones, neuromodulators and ligands. The αz subunit is myristoylated near the N-terminus.

Application

Anti-Gαx/z antibody produced in rabbit is suitable for western blot analysis at a working dilution of 1:100-1:200 using plasma membrane fractions.

Features and Benefits

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Biochem/physiol Actions

The gene GNAZ (guanine nucleotide binding protein (G protein), αz polypeptide) encodes an α subunit of guanine nucleotide binding proteins. The α-subunit contains a guanine-binding domain that is in its inactive state when it is occupied by GDP. Upon activation, GDP is replaced with GTP, causing the dissociation of the α-subunit from the βγ-subunit complex. This enables the Gα-GTP complex to bind to and regulate specific signaling pathways. GTP is then hydrolyzed, allowing for re-association of the α-subunit with the βγ-subunit complex. When coupled to phospholipase C, the α subunits may have a role in pertussis toxin-insensitive pathways.

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