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G5171 Sigma

Anti-Granulocyte Colony Stimulating Factor antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-G-CSF

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Hematopoietic Cytokines,
species reactivity   human
application(s)   neutralization: suitable
  western blot: 1-2 μg/mL
clone   polyclonal
antibody form   IgG fraction of antiserum
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... CSF3(1440)
biological source   goat
conjugate   unconjugated

Description

Immunogen

purified, recombinant human granulocyte colony stimulating factor, expressed in E. coli.

General description

Mature myeloid cells are derived from bone-marrow derived precursor cells by the activity of three colony stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). The expression of G-CSF is the result of activation of pathways in response to tumor necrosis factor-α, LPS and toll-like receptor ligands. The pathways that induce the effects of G-CSF are PI3K, ERK1/2 and p38. The generation of neutrophils and induction of the circulation of hematopoietic stem cells from the bone marrow are the main functions of G-CSF. There are additional activities attributed to G-CSF such as neuroprotection, immunomodulation and generation of cardiac cells and dendritic cells. Large quantities of G-CSF are secreted in a variety of myeloid and non-myeloid cancers and rheumatoid arthritis
Monoclonal anti-granulocyte colony stimulating factor recognizes human G-CSF.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Application

Anti-granulocyte colony stimulating factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. The antibody is also suitable for neutralization assays.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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G5421 Monoclonal Anti-Granulocyte Colony Stimulating Factor antibody produced in rat, clone 67604, purified immunoglobulin, lyophilized powder
G0540 Monoclonal Anti-Granulotyte Colony Stimulating Factor antibody produced in rat, clone 67604.111, purified immunoglobulin, lyophilized powder
G0407 Granulocyte colony-stimulating factor human, G-CSF, recombinant, expressed in E. coli, suitable for cell culture
G1029 Monoclonal Anti-Granulocyte Colony Stimulating Factor antibody produced in mouse, clone 3316.111, purified immunoglobulin, lyophilized powder
G8160 Granulocyte Colony-Stimulating Factor from mouse, G-CSF, recombinant, expressed in E. coli, suitable for cell culture

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