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G5417 Sigma

Glycine

PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture

Synonym: Aminoacetic acid, Aminoethanoic acid, Glycocoll

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Properties

Related Categories Amino Acids, Analytical/Chromatography, Biochemicals and Reagents, Pharmacopoeia, Pharmacopoeia A-Z,
Quality Level   GMP-COMPENDIA
biological source   from non-animal source
grade   EP
  JP
  USP
InChI Key   DHMQDGOQFOQNFH-UHFFFAOYSA-N
product line   PharmaGrade
assay   ≥98.5%
form   crystalline powder
mfr. no.   Ajinomoto
impurities   endotoxin, heavy metals, trace metals, residual solvents, tested
pH   5.9-6.4
pKa (25 °C)   2.35
mp   240 °C (dec.)(lit.)
solubility   H2O: soluble100 mg/mL
UV absorption   λ: 260 nm Amax: ≤0.04
  λ: 260 nm Amax: -0.006
  λ: 280 nm Amax: ≤0.04
  λ: 280 nm Amax: -0.003
suitability   suitable for cell culture
  suitable for manufacturing use
foreign activity   cytotoxicity, tested
Gene Information   rat ... Grin2a(24409)

Description

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Linkage

To request the Enhanced Quality Product Documentation for this product, submit a PharmaGrade Product Information Request Form. Please note that access to the Enhanced Quality Product Documentation for this product requires a confidentiality disclosure agreement.

Application

Glycine is a non-essential amino acid. It is the simplest of the amino acids and plays various roles in biology. It is structurally unique among the biological amino acids in that it does not have an asymmetric center, and thus is not chiral. It is commonly used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles

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Peer-Reviewed Papers
15

References

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