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G5650 Sigma

Grb2 SH2-domain Protein A fusion protein

≥90% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

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Properties

recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   lyophilized powder
composition   Protein, 3-5%
storage temp.   −20°C
Gene Information   human ... GRB2(2885)

Description

Biochem/physiol Actions

A key protein in signal transduction, Grb2 transfers the signal from tyrosine kinases such as epidermal growth factor (EGF) receptor to the small G protein Ras. GRB2 contains an SH2 (Src homology 2) domain which enables binding to tyrosine-phosphorylated receptors. The fusion protein enables detection and purification of tyrosine-phosphorylated proteins (i.e., tyrosine-phosphorylated EGF receptor), utilizing the affinity of protein A for the Fc domain of IgG.

Other Notes

A 37 kDa fusion protein containing the SH2 domain of mouse Grb2 (amino acids 50-161) fused to protein A.

Packaging

Package size based on protein content

Physical form

Contains potassium phosphate and sodium chloride

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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