|Related Categories||Acidic Glycosphingolipids, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,|
Suggested to be a modulator of cell growth and signal transduction. Accumulates in the nervous system of patients with GM1 gangliosidosis. Used for the preparation of GM1 derivatives containing different fatty acids, fluorescent tags, or other residues.
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
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~98%, lyophilized powder
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from bovine brain, ~95%
Tubaro, E., et al. Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Soc. 248, 175, (1993)
LIGA20, a lyso derivative of ganglioside GM1, given orally after cortical thrombosis reduces infarct size and associated cognition deficit. Kharlamoy, A., et al. Proc. Natl. Acad. Sci. U. S. A. 91, 6303, (1994)
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